癌症中的巨噬细胞移动抑制因子

Macrophage migration inhibitory factor in cancer.

作者信息

Yasasever Vildan, Camlica Hakan, Duranyildiz Derya, Oguz Hilal, Tas Faruk, Dalay Nejat

机构信息

Department of Basic Oncology, Institute of Oncology, University of Istanbul, Istanbul, Turkey.

出版信息

Cancer Invest. 2007 Dec;25(8):715-9. doi: 10.1080/07357900701560695.

DOI:10.1080/07357900701560695

PMID:18058468

Abstract

The objective of this study was to investigate the expression of macrophage migration inhibitory factor (MIF) in patients with colorectal cancer (GIS) and malignant melanoma (MM). The study group consists of pathologically verified colorectal cancer (n = 63) and malignant melanoma (n = 65) patients and healthy controls (n = 25). Serum MIF concentrations were determined by enzyme-linked immunosorbent assay. Serum values of the patients were significantly higher than the controls (p < 0.001 for GIS, p = 0.032 for MM). Diagnostic sensitivity and specificity were calculated for MIF for colorectal and malignant melanoma. The results demonstrate that colorectal cancer express and secrete large amounts of MIF.

摘要

本研究的目的是调查巨噬细胞移动抑制因子（MIF）在结直肠癌（GIS）和恶性黑色素瘤（MM）患者中的表达情况。研究组包括经病理证实的结直肠癌患者（n = 63）、恶性黑色素瘤患者（n = 65）以及健康对照者（n = 25）。采用酶联免疫吸附测定法测定血清MIF浓度。患者的血清值显著高于对照组（GIS患者p < 0.001，MM患者p = 0.032）。计算了MIF对结直肠癌和恶性黑色素瘤的诊断敏感性和特异性。结果表明，结直肠癌表达并分泌大量MIF。