新型N1-无环C4和C6-二取代吡唑并[3,4-d]嘧啶核苷的合成及其抗单纯疱疹病毒活性
Synthesis and anti-HSV activity of new N1-acyclic C4 and C6-disubstituted pyrazolo[3,4-d]pyrimidine nucleosides.
作者信息
Moukha-chafiq Omar, Taha Mohamed Labd, Mouna Abdelmalek
机构信息
Facultes des Sciences, Laboratoire de Chimie Bio-Organique Appliquée, Agadir, Maroc.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):1107-10. doi: 10.1080/15257770701521102.
PMID:18058546
Abstract
Several N(1)-(2-hydroxyethoxy)methyl, (4-hydroxybutyl) and (2,3-dihydroxy-1-propoxy)methyl-C(4),C(6)-disubstituted-1H-pyrozolo[3,4-d]pyrimidines were synthesized. Some of them were evaluated against herpes simplex virus 1 and 2 replications in E(6)SM cells.
摘要
合成了几种N(1)-(2-羟基乙氧基)甲基、(4-羟基丁基)和(2,3-二羟基-1-丙氧基)甲基-C(4),C(6)-二取代-1H-吡唑并[3,4-d]嘧啶。其中一些在E(6)SM细胞中针对单纯疱疹病毒1型和2型复制进行了评估。
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