Synthesis and antiviral activity of some C2-, C4-, and C6-substituted pyrazolo[3,4-D]pyrimidine acyclonucleosides with the alkylating chains of ACV, HBG, and ISO-DHPG.
作者信息
Moukha-Chafiq Omar, Taha Mohamed Labd, Lazrek Hassan Bihi, Vasseur Jean-Jacques, Clercq Erik De
机构信息
Laboratoire de Chimie Bio-Organique, Faculte des Sciences, Agadir, Maroc.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2006;25(8):849-60. doi: 10.1080/15257770600793802.
PMID:16901816
Abstract
A useful route to obtain trisubstituted pyrazolo[3,4-d]pyrimidines 14-17 is described. Those later were coupled with the alkylating agents 18-20 as in ACV, HBG, and iso-DHPG to give, after deprotection, the desired acylonucleosides 33-44. Almost all of the new compounds were evaluated for their inhibitory effects against the replication of various DNA viruses in culture.
摘要
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