某些噻吩并[2,3-d]嘧啶核苷的合成与抗病毒筛选
Synthesis and antiviral screening of some thieno[2,3-d]pyrimidine nucleosides.
作者信息
Rashad A E, Ali M A
机构信息
Photochemistry Department, National Research Centre, Dokki, Egypt.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2006;25(1):17-28. doi: 10.1080/15257770500377730.
Some cyclic and acyclic nucleosides of thieno[2,3-d]-pyrimidine derivatives were synthesized via the reaction of compounds 1 and 2 or 3 and 4 with 2-chloroethyl methyl ether or 2,3,4, 6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide. Nucleosides 9, 10, 15, and 16 were tested as antiviral agents against herpes simplex virus type-1 (HSV-1) and hepatitis-A virus (HAV). Compound 15 showed the highest effect on HSV-1 than the other three compounds, while the four tested compounds did not show any activity against HAV.
通过化合物1和2或3和4与2-氯乙基甲基醚或2,3,4,6-四-O-乙酰基-α-D-吡喃葡萄糖基溴的反应，合成了一些噻吩并[2,3-d]嘧啶衍生物的环状和非环状核苷。对核苷9、10、15和16进行了抗1型单纯疱疹病毒（HSV-1）和甲型肝炎病毒（HAV）的抗病毒剂测试。化合物15对HSV-1的作用比其他三种化合物更高，而这四种受试化合物对HAV均未显示出任何活性。
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