Manzardo S, Coppi G
Centro Ricerche, Poli Industria Chimica, Rozzano (MI).
Boll Chim Farm. 1991 Nov;130(10):399-401.
The Authors report the protective activity of some compounds against the toxicity of acetaldehyde, acrolein and formaldehyde in the rat. The compounds were orally administered 30 min before and 5 hours after the toxicant aldehyde administration (acetaldehyde 2150 mg/kg os; acrolein 75 mg/kg os; formaldehyde 950 mg/kg os). L-cysteine and L-ascorbic acid showed a good protective activity against the three toxicant aldehydes. Cysteamine, BHT and propyl gallate showed activity against acetaldehyde and formaldehyde. Quercetin was active only against acetaldehyde whereas alpha-tocopherol was inactive.
作者报告了某些化合物对大鼠体内乙醛、丙烯醛和甲醛毒性的保护作用。这些化合物在给予有毒醛类（乙醛2150毫克/千克口服；丙烯醛75毫克/千克口服；甲醛950毫克/千克口服）前30分钟和后5小时口服给药。L-半胱氨酸和L-抗坏血酸对这三种有毒醛类显示出良好的保护作用。半胱胺、丁基羟基甲苯和没食子酸丙酯对乙醛和甲醛有作用。槲皮素仅对乙醛有活性，而α-生育酚无活性。
