Nandagopal Radha, Laverdière Caroline, Mulrooney Daniel, Hudson Melissa M, Meacham Lillian
Division of Pediatric Endocrinology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Ga., USA.
Horm Res. 2008;69(2):65-74. doi: 10.1159/000111809. Epub 2007 Dec 5.
Pediatric oncologists are curing increasing numbers of patients with childhood cancer, and most children diagnosed with a malignancy may now be expected to become long-term survivors. As the number of childhood cancer survivors grows, so too does the need for evidence-based surveillance of the long-term effects of cancer therapy. Long-term effects involving the endocrine system represent a frequent complication of therapy. The Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers(COG LTFUG), most recently updated in 2006, provide a summary of the known endocrine late effects of surgery, radiation, chemotherapy, and stem cell transplant. This paper summarizes the scope and nature of the endocrine late effects of childhood cancer therapy based upon a review of the pertinent medical literature, and demonstrates how pediatric oncologists can use these guidelines in clinical practice.
儿科肿瘤学家治愈的儿童癌症患者数量日益增加，现在大多数被诊断患有恶性肿瘤的儿童有望成为长期幸存者。随着儿童癌症幸存者数量的增加，对癌症治疗长期影响进行循证监测的需求也在增加。涉及内分泌系统的长期影响是治疗中常见的并发症。儿童肿瘤学组发布的《儿童、青少年和青年癌症幸存者长期随访指南》（COG LTFUG）最近一次更新是在2006年，该指南总结了手术、放疗、化疗和干细胞移植已知的内分泌晚期效应。本文基于对相关医学文献的综述，总结了儿童癌症治疗内分泌晚期效应的范围和性质，并展示了儿科肿瘤学家如何在临床实践中使用这些指南。
