Tews Daniel, Schulz Ansgar, Denzer Christian, von Schnurbein Julia, Ceccarini Giovanni, Debatin Klaus-Michael, Wabitsch Martin
Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, 89075 Ulm, Germany.
Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, 89075 Ulm, Germany.
J Clin Med. 2021 Apr 8;10(8):1559. doi: 10.3390/jcm10081559.
Survivors of childhood cancer are at high risk of developing metabolic diseases in adulthood. Recently, several patients developing partial lipodystrophy following hematopoietic stem cell transplantation (HSCT) have been described. In this review, we summarize the cases described so far and discuss potential underlying mechanisms of the disease. The findings suggest that HSCT-associated lipodystrophies may be seen as a novel form of acquired lipodystrophy.
儿童癌症幸存者成年后患代谢性疾病的风险很高。最近，已有数例造血干细胞移植（HSCT）后发生部分脂肪营养不良的患者被报道。在本综述中，我们总结了迄今为止所描述的病例，并探讨了该疾病潜在的发病机制。研究结果表明，HSCT相关的脂肪营养不良可能被视为一种新型的获得性脂肪营养不良。
