Sato Satoshi, Kawashima Hisashi, Kashiwagi Yasuyo, Ushio Nobuhisa, Nagai Makoto, Takekuma Kouji, Hoshika Akinori
Department of Pediatrics, Tokyo Medical University.
Arerugi. 2007 Nov;56(11):1378-83.
Chlamydia pneumoniae is a frequent causative agent of acute respiratory disease and has been recently reported as a possible cause of asthma. We investigated the prevalence of C. pneumoniae infections in childhood patients with acute exacerbations of asthma.
One hundred twenty-six childhood patients with acute exacerbations of asthma, 77 with acute bronchitis and 22 Respiratory syncytial virus infections were studied. Serum samples were obtained and tested for C. pneumoniae-specific IgM antibody by Enzyme-Linked ImmunoSorbent Assay (ELISA).
C. pneumoniae IgM-positive results were observed in 48.4% (Index value>or=1.60) and 23% (Index value>or=1.10) of patients with acute exacerbations of asthma. The prevalence of C. pneumoniae-specific IgM was significantly higher in asthma cases than in other subjects (p<0.05).
Our data suggest that C. pneumoniae infection may trigger acute exacerbations of childhood asthma.
肺炎衣原体是急性呼吸道疾病的常见病原体，最近有报道称它可能是哮喘的病因。我们调查了哮喘急性加重期儿童患者中肺炎衣原体感染的患病率。
研究了126例哮喘急性加重期儿童患者、77例急性支气管炎患者和22例呼吸道合胞病毒感染患者。采集血清样本，采用酶联免疫吸附试验（ELISA）检测肺炎衣原体特异性IgM抗体。
哮喘急性加重期患者中，48.4%（指数值≥1.60）和23%（指数值≥1.10）的患者肺炎衣原体IgM检测呈阳性。哮喘病例中肺炎衣原体特异性IgM的患病率显著高于其他受试者（p<0.05）。
我们的数据表明，肺炎衣原体感染可能引发儿童哮喘急性加重。
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