Annagür Ali, Kendirli S G, Yilmaz M, Altintas D U, Inal A
Department of Pediatric Allergy and Immunology, Faculty of Medicine, University of Cukurova, Adana, Turkey.
J Trop Pediatr. 2007 Oct;53(5):313-8. doi: 10.1093/tropej/fmm040. Epub 2007 May 29.
Asthma is a chronic inflammatory airway disease characterized by variable airway obstruction and bronchial hyperresponsiveness. There are many factors affecting the development and severity of childhood asthma such as genetic predisposition, atopy, environmental factors, obesity, diet, socioeconomic status, and infectious triggers. In the present study we aimed to investigate the frequency of Mycdoplasma pneumoniae, Chlamydia pneumoniae, and Helicobacter pylori infections in asthmatic children. We investigated also whether there is a relationship between these agents and asthma attacks.
Seventy-nine asthmatic children (46 males, aged 5-15 years) were included in study. The study group was divided into two groups: group 1 consisted of 37 children with asthma attacks and group 2 consisted of 42 children with stable asthma. As a control group we studied 36 healthy children. Pulmonary function tests, skin prick tests for common allergens were performed; serum total IgE, phadiatop, specific IgM and IgG antibody levels (ELISA) for M. pneumoniae, C. pneumoniae and H. pylori were measured in all patients.
Mycoplasma IgM and Chlamidia IgM were positive in 8.1% (3 patients) and 18.9% (7 patients) of group 1 patients, respectively. There was a statistically significant difference for Mycoplasma IgM (p = 0.031) and Chlamidia IgM (p = 0.03) between group1 and other two groups. We have not found significant difference for M. pneumoniae IgG, C. pneumoniae IgG and H. pylori IgM and IgG among groups.
M. Pneumoniae and C. Pneumoniae may play a role in development of asthma exacerbations in childhood. We could not find a relationship between H. Pylori and asthma.
哮喘是一种慢性炎症性气道疾病，其特征为气道阻塞多变和支气管高反应性。有许多因素影响儿童哮喘的发生发展及严重程度，如遗传易感性、特应性、环境因素、肥胖、饮食、社会经济地位和感染诱因。在本研究中，我们旨在调查哮喘儿童中肺炎支原体、肺炎衣原体和幽门螺杆菌感染的频率。我们还研究了这些病原体与哮喘发作之间是否存在关联。
79名哮喘儿童（46名男性，年龄5 - 15岁）纳入研究。研究组分为两组：第1组由37名有哮喘发作的儿童组成，第2组由42名哮喘病情稳定的儿童组成。作为对照组，我们研究了36名健康儿童。进行了肺功能测试、常见变应原的皮肤点刺试验；测定了所有患者血清总IgE、嗜多价变应原试剂、肺炎支原体、肺炎衣原体和幽门螺杆菌特异性IgM和IgG抗体水平（酶联免疫吸附测定）。
第1组患者中肺炎支原体IgM和肺炎衣原体IgM分别有8.1%（3例）和18.9%（7例）呈阳性。第1组与其他两组之间，肺炎支原体IgM（p = 0.031）和肺炎衣原体IgM（p = 0.03）存在统计学显著差异。各组之间肺炎支原体IgG、肺炎衣原体IgG以及幽门螺杆菌IgM和IgG未发现显著差异。
肺炎支原体和肺炎衣原体可能在儿童哮喘加重的发生中起作用。我们未发现幽门螺杆菌与哮喘之间存在关联。
