[小柴胡汤的药物淋巴细胞刺激试验（DLST）评估]

[Evaluation of the drug lymphocyte stimulation test (DLST) with shosaikoto].

作者信息

Nakayama Masayuki, Bando Masashi, Hosono Tatsuya, Yamasawa Hideaki, Ohno Shoji, Sugiyama Yukihiko

机构信息

Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University.

出版信息

Arerugi. 2007 Nov;56(11):1384-9.

PMID:18059152

Abstract

BACKGROUND

Our aim is to evaluate the significance of DLST by Shosaikoto.

METHODS

We clinically evaluated 3 cases of drug-induced pneumonia assumed to be caused by Shosaikoto, and we performed DLST of Shosaikoto for healthy controls, and compared the data with drug-induced pneumonia cases of Shosaikoto.

RESULTS

As clinical characteristics of 3 cases, 2 cases were positive for hepatitis C virus antibody, and 1 case was positive for DLST of Shosaikoto. The observed chest high-resolution CT (HRCT) findings showed hypersensitivity pneumonia (HP) pattern in all 3 cases. Prognosis was good in all 3 cases. DLST of Shosaikoto was positive in 27.5% of healthy controls. Stimulation index (S.I.) of DLST in drug-induced pneumonia cases increased depending on drug dilution density, compared to that of healthy controls.

CONCLUSION

DLST of Shosaikoto showed high false-positive rate. However, we may be able to distinguish the true-positive cases with the false-positive cases by comparing the S.I. of DLST according to drug dilution density.

摘要

背景

我们的目的是评估小柴胡汤的迟发型皮肤过敏试验（DLST）的意义。

方法

我们对3例推测由小柴胡汤引起的药物性肺炎进行了临床评估，并对健康对照者进行了小柴胡汤的DLST，并将数据与小柴胡汤所致药物性肺炎病例进行了比较。

结果

作为3例的临床特征，2例丙型肝炎病毒抗体阳性，1例小柴胡汤的DLST阳性。观察到的胸部高分辨率CT（HRCT）表现显示所有3例均为过敏性肺炎（HP）模式。所有3例预后良好。小柴胡汤的DLST在27.5%的健康对照者中呈阳性。与健康对照者相比，药物性肺炎病例中DLST的刺激指数（S.I.）根据药物稀释密度而增加。