Nakajima Hirokazu, Sawaguchi Hirochiyo, Tsuji Fumio, Miyamoto Takeaki, Nakajima Shigenori, Tohda Yuji
Department of Respiratory Medicine and Allergy, Nara Hospital, Kinki University School of Medicine.
Arerugi. 2008 Jan;57(1):59-63.
We present a case of acute respiratory distress syndrome (ARDS) caused by allergic reactions to shiniseihaito. An 84-year-old woman showed acute interstitial pneumonia followed by ARDS after taking shiniseihaito for the treatment of rhinitis. The ARDS were markedly improved with corticosteroid therapy. This case was diagnosed as being induced by shiniseihaito because it was compatible with 4 of 5 of Camus's criteria. The stimulation index of the drug lymphocyte stimulation test with shiniseihaito increased after corticosteroid therapy had been tapered and suggested that the mechanism of acute interstitial pneumonia in this case was allergic reaction induced by shiniseihaito. This is the seventh reported case of drug induced lung injury by shiniseihaito. We recommend careful observation when this medicine is prescribed.
我们报告一例由对柴朴汤过敏反应引起的急性呼吸窘迫综合征（ARDS）。一名84岁女性在服用柴朴汤治疗鼻炎后出现急性间质性肺炎，随后发展为ARDS。经皮质类固醇治疗后，ARDS明显改善。该病例被诊断为由柴朴汤诱发，因为它符合加缪标准中5条中的4条。在皮质类固醇治疗逐渐减量后，柴朴汤药物淋巴细胞刺激试验的刺激指数升高，提示该病例急性间质性肺炎的机制是柴朴汤诱发的过敏反应。这是第七例报道的由柴朴汤引起的药物性肺损伤病例。我们建议在开具此药处方时要仔细观察。
