Ebbesson Sven O E, Tejero M Elizabeth, Nobmann Elizabeth D, Lopez-Alvarenga Juan Carlos, Ebbesson Lars, Romenesko Terri, Carter Elizabeth A, Resnick Helaine E, Devereux Richard B, MacCluer Jean W, Dyke Bennett, Laston Sandra L, Wenger Charlotte R, Fabsitz Richard R, Comuzzie Anthony G, Howard Barbara V
Norton Sound Health Corp, Nome, AK, USA.
J Cardiometab Syndr. 2007 Fall;2(4):244-9. doi: 10.1111/j.1559-4564.2007.07393.x.
Fatty acids (FAs) have been related to changes in glucose and lipid metabolism. In this article, the authors assess the association between intake of specific FAs and components of the metabolic syndrome (MS) in adult Eskimos. A total of 691 Inupiat Eskimos (325 men and 366 women), aged 34 to 75 years, were examined as part of the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. The investigation included a physical examination, blood pressure measurements, blood sampling under fasting conditions, 2-hour oral glucose tolerance test, and a personal interview including a validated food frequency questionnaire. Components of MS were defined according to the Third Report of the National Cholesterol Education Program Adult Treatment Panel criteria. Consumption of individual FAs showed associations with MS components. Long-chain omega-3 FAs, from fish and sea mammals, were associated with lower blood pressure, serum triglycerides, and 2-hour glucose and higher high-density lipoprotein cholesterol, fasting insulin, and homeostasis model assessment. Saturated fat consumption was associated with higher triglyceride levels and blood pressure. Trans-FA consumption was associated with higher blood pressure. Consumption of long-chain omega-3 FAs from marine sources may improve certain MS components, and thus may reduce risk for cardiovascular disease. High consumption of saturated FAs and trans-FAs may have an adverse effect on MS.
脂肪酸（FAs）与葡萄糖及脂质代谢变化有关。在本文中，作者评估了成年爱斯基摩人特定脂肪酸摄入量与代谢综合征（MS）各组分之间的关联。作为阿拉斯加原住民冠状动脉疾病遗传学（GOCADAN）研究的一部分，共检查了691名年龄在34至75岁之间的因纽皮特爱斯基摩人（325名男性和366名女性）。调查包括体格检查、血压测量、空腹条件下的血液采样、2小时口服葡萄糖耐量试验，以及一次个人访谈，其中包括一份经过验证的食物频率问卷。MS的各组分根据美国国家胆固醇教育计划成人治疗小组第三次报告的标准进行定义。个体脂肪酸的摄入量与MS各组分存在关联。来自鱼类和海洋哺乳动物的长链ω-3脂肪酸与较低的血压、血清甘油三酯和2小时血糖以及较高的高密度脂蛋白胆固醇、空腹胰岛素和稳态模型评估值相关。饱和脂肪的摄入与较高的甘油三酯水平和血压相关。反式脂肪酸的摄入与较高的血压相关。食用海洋来源的长链ω-3脂肪酸可能会改善某些MS组分，从而可能降低心血管疾病风险。高摄入饱和脂肪酸和反式脂肪酸可能会对MS产生不利影响。
