Hollox Edward J, Huffmeier Ulrike, Zeeuwen Patrick L J M, Palla Raquel, Lascorz Jesús, Rodijk-Olthuis Diana, van de Kerkhof Peter C M, Traupe Heiko, de Jongh Gys, den Heijer Martin, Reis André, Armour John A L, Schalkwijk Joost
Department of Genetics, University of Leicester, Leicester LE1 7RH, UK.
Nat Genet. 2008 Jan;40(1):23-5. doi: 10.1038/ng.2007.48. Epub 2007 Dec 2.
Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis.
银屑病是一种常见的具有强大遗传成分的炎症性皮肤病。我们分析了179名荷兰银屑病患者和272名对照，以及319名德国银屑病患者和305名对照中人类8号染色体上β-防御素区域的基因组拷贝数多态性。两个队列的比较均显示，β-防御素基因较高的基因组拷贝数与银屑病风险之间存在显著关联。
