Yadav Tejpal, Yadav Hemant Kumar Singh, Raizaday Abhay, Alam Md Sabir
Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, India.
Department of Pharmaceutics, College of Pharmacy, JSS Academy of Technical Education, Noida, Uttar Pradesh, India.
Bioimpacts. 2024 Aug 11;15:30341. doi: 10.34172/bi.30341. eCollection 2025.
Psoriasis is a chronic condition that can strike at any age. This sickness is associated with inflammatory problems that impact all humans in the world. Psoriasis is more common in Scandinavians than in Asian and African populations due to a combination of factors such as age, gender, geographic location, ethnicity, genetic and environmental factors. Immune stimulation, genetic contribution, antimicrobial peptides, and other significant triggers such as medicines, immunizations, infections, trauma, stress, obesity, alcohol intake, smoking, air pollution, sun exposure, and particular disorders cause psoriasis. Numerous clinical research investigations are now underway, and therapeutic alternatives are available. However, these therapies only improve symptoms and do not accomplish a complete cure; they also have dangerous and undesirable side effects. Natural products have gained popularity recently due to their great effectiveness, safety, and low toxicity. Natural formulations of various nanocarriers like liposomes, lipospheres, nanogels, emulgel, nanostructured lipid carriers, nanosponge, nanofibers, niosomes, nanomiemgel, nanoemulsions, nanospheres, cubosomes, microneedles, nanomicelles, ethosomes, nanocrystals, and foams, have significantly contributed and encouraged advancement in psoriasis disease treatment. These phytochemical-loaded new nanoformulations address several issues associated with natural products in conventional dosage forms, such as instability, poor solubility, and limited bioavailability. This article reviews some of the intriguing phytochemicals, as well as their possible molecular target locations and mechanisms of action, which may assist in the development of more specific and selective antipsoriatic medicines. Exploring and understanding phytochemicals' functions will allow for more site-specific psoriasis treatment techniques. This review concluded the psoriasis disease with phytoconstituent loaded herbal or polyherbal nanocarriers and their mechanistic approach.
银屑病是一种可在任何年龄发病的慢性疾病。这种疾病与影响全世界所有人的炎症问题相关。由于年龄、性别、地理位置、种族、遗传和环境等多种因素的综合作用，银屑病在斯堪的纳维亚人中比在亚洲和非洲人群中更为常见。免疫刺激、遗传因素、抗菌肽以及其他重要诱因，如药物、免疫接种、感染、创伤、压力、肥胖、酒精摄入、吸烟、空气污染、阳光照射和某些疾病，都会引发银屑病。目前正在进行大量的临床研究调查，并且有多种治疗选择。然而，这些疗法仅能改善症状，无法实现完全治愈；它们还具有危险且不良的副作用。天然产物近来因其高效、安全和低毒性而受到欢迎。各种纳米载体的天然制剂，如脂质体、脂质球、纳米凝胶、乳胶、纳米结构脂质载体、纳米海绵、纳米纤维、非离子表面活性剂囊泡、纳米微凝胶、纳米乳液、纳米球、立方液晶、微针、纳米胶束、醇质体、纳米晶体和泡沫，对银屑病疾病治疗的进展做出了重大贡献并起到了推动作用。这些负载植物化学物质的新型纳米制剂解决了传统剂型中天然产物存在的几个问题，如稳定性差、溶解度低和生物利用度有限等。本文综述了一些有趣的植物化学物质，以及它们可能的分子靶点位置和作用机制，这可能有助于开发更具特异性和选择性的抗银屑病药物。探索和理解植物化学物质的功能将有助于实现更针对特定部位的银屑病治疗技术。本综述总结了负载植物成分的草药或多草药纳米载体治疗银屑病疾病及其作用机制。
