Leslie William D, Weiler Hope A, Nyomba B L Grégoire
Faculty of Medicine (C5121), 409 Tache Ave., University of Manitoba, Winnipeg, MB R2H 2A6, Canada.
Appl Physiol Nutr Metab. 2007 Dec;32(6):1065-72. doi: 10.1139/H07-068.
The purpose of this study was to compare patterns of adiposity and soft tissue composition in First Nations and white Canadian women. A population-based cross-sectional study was performed. A random age-stratified sample of 206 urban First Nations women and 177 white women was recruited. Soft tissue composition was analyzed with dual-energy X-ray absorptiometry. Analysis of covariance (ANCOVA) models were used to assess ethnicity in models that adjusted for body mass, body mass index (BMI), and socio-demographic factors. Obesity (BMI>or=30.0 kg/m2) was more common in First Nations women (48.1%) than in white women (36.2%, Fisher's exact test p=0.012). Mean trunk fat tissue mass fraction and total body fat mass fraction (as a percent of soft tissue) were greater in First Nations women than in white women (p<0.0001). Trunk lean tissue was also greater in First Nations women (p=0.027), but total body lean tissue was similar. The mean trunk adiposity index was strongly related to ethnicity (First Nations +0.5%+/-2.5% versus white -1.7%+/-2.6%, p<0.0001). Preferential fat accumulation in the trunk of First Nations women persisted after adjustment for body mass, BMI, and other socio-demographic variables (p<0.0001). First Nations women differ from white women in terms of fat and lean tissue mass and distribution. First Nations women had a preferential increase in trunk fat and this may contribute to high reported rates of diabetes, metabolic syndrome, and cardiovascular events.
本研究的目的是比较原住民和加拿大白人女性的肥胖模式及软组织成分。开展了一项基于人群的横断面研究。招募了206名城市原住民女性和177名白人女性的随机年龄分层样本。采用双能X线吸收法分析软组织成分。在调整了体重、体重指数（BMI）和社会人口统计学因素的模型中，使用协方差分析（ANCOVA）模型评估种族差异。肥胖（BMI≥30.0kg/m²）在原住民女性中（48.1%）比在白人女性中（36.2%）更常见（Fisher精确检验p = 0.012）。原住民女性的平均躯干脂肪组织质量分数和全身脂肪质量分数（占软组织的百分比）高于白人女性（p<0.0001）。原住民女性的躯干瘦组织也更多（p = 0.027），但全身瘦组织相似。平均躯干肥胖指数与种族密切相关（原住民+0.5%±2.5%，白人-1.7%±2.6%，p<0.0001）。在调整了体重、BMI和其他社会人口统计学变量后，原住民女性躯干中脂肪的优先积累仍然存在（p<0.0001）。原住民女性与白人女性在脂肪和瘦组织的质量及分布方面存在差异。原住民女性躯干脂肪优先增加，这可能导致所报告的糖尿病、代谢综合征和心血管事件的高发病率。
