Müller Suzana, Francesconi Carlos Fernando de Magalhães, Maguilnik Ismael, Breyer Helenice Pankowsky
Digestive Endoscopy Unit, Gastroenterology Division, Hospital de Clínicas de Porto Alegre, RS, Brazil.
Arq Gastroenterol. 2007 Jul-Sep;44(3):244-9. doi: 10.1590/s0004-28032007000300013.
The cleansing of the colon for a colonoscopy exam must be complete so as to allow the visualization and inspection of the intestinal lumen. The ideal cleansing agent should be easily administered, have a low cost, and minimum collateral effects. Sodium picosulfate together with the magnesium citrate is a cathartic stimulant and mannitol is an osmotic laxative, both usually used for this purpose.
Assess the colon cleanliness comparing the use of mannitol and sodium picosulfate as well as evaluate the level of patient satisfaction, the presence of foam, pain, and abdominal distension in hospitalized patients undergoing colonoscopy.
A prospective, randomized, single-blind study with 80 patients that compared two groups: mannitol (40) and sodium picosulfate (40). Both groups received the same dietary orientation. The study was approved by the hospital's Ethics and Research Committee. The endoscopist was blind to the type of preparation. Outcomes evaluated: level of the colons cleanliness, patients satisfaction, the presence of foam, abdominal pain and distension, and the duration of the exam. The data was analyzed by means of the chi-squared test for proportions and Mann-Whitney for independent samples.
There were no statistically significant differences between the groups in relation to the level of the colon's cleanliness, patients satisfaction, the presence of foam, abdominal pain, and the duration of the exam. Fifteen percent of the exams of the mannitol group were interrupted while from the sodium picosulfate group it was 5%. The presence of foam was similar for both groups. The average duration for carrying out the exam was 28.44 minutes for the mannitol group and 35.59 minutes for the sodium picosulfate group. Abdominal distension was more frequent in the mannitol group. If they would have to do the same exam, the answer was that 80% said yes from the mannitol group and 92.5% from the sodium picosulfate group.
The quality of the colon preparation, foam formation, exam duration, and the collateral effects (nauseas, vomiting, and abdominal pain) were similar in both kinds of preparations. Abdominal distension was greater in the mannitol group. Both methods of preparation were well accepted by the hospitalized patients.
为进行结肠镜检查而进行的结肠清洁必须彻底，以便能够观察和检查肠腔。理想的清洁剂应易于给药、成本低且副作用最小。比沙可啶钠与枸橼酸镁是一种刺激性泻药，甘露醇是一种渗透性泻药，两者通常都用于此目的。
比较使用甘露醇和比沙可啶钠时的结肠清洁程度，并评估接受结肠镜检查的住院患者的满意度、泡沫的出现情况、疼痛和腹胀情况。
一项前瞻性、随机、单盲研究，对80名患者进行分组比较：甘露醇组（40例）和比沙可啶钠组（40例）。两组接受相同的饮食指导。该研究获得了医院伦理与研究委员会的批准。内镜检查医师对准备类型不知情。评估的结果包括：结肠清洁程度、患者满意度、泡沫的出现情况、腹痛和腹胀情况以及检查持续时间。数据通过比例的卡方检验和独立样本的曼-惠特尼检验进行分析。
两组在结肠清洁程度、患者满意度、泡沫的出现情况、腹痛和检查持续时间方面无统计学显著差异。甘露醇组15%的检查被中断，而比沙可啶钠组为5%。两组泡沫的出现情况相似。甘露醇组进行检查的平均持续时间为28.44分钟，比沙可啶钠组为35.59分钟。甘露醇组腹胀更常见。如果必须再次进行相同的检查，甘露醇组80%的患者表示愿意接受，比沙可啶钠组为92.5%。
两种制剂在结肠准备质量、泡沫形成、检查持续时间和副作用（恶心、呕吐和腹痛）方面相似。甘露醇组腹胀更严重。两种准备方法均为住院患者所接受。
