Shor Renana, Wainstein Julio, Oz David, Boaz Mona, Matas Zipora, Fux Asora, Halabe Aaron
Dept. of Internal Medicine, The Edith Wolfson Medical Centre, Sackler School of Medicine, Tel Aviv University, Holon, Israel.
Clin Res Cardiol. 2008 Apr;97(4):227-33. doi: 10.1007/s00392-007-0611-z. Epub 2007 Dec 1.
High density lipoprotein (HDL) plays an important role as an anti-atherogenic molecule, but also possesses anti-inflammatory and anti-angiogenic properties. The effect of extremely low levels of HDL on the risk of sepsis and malignancy were therefore examined.
A retrospective analysis of patients hospitalized at the Edith Wolfson Medical center was conducted. Patients were divided into Group 1: 108 patients with serum HDL levels < or =20 mg/dl. Group 2: 96 patients with serum HDL levels > or =65 mg/dl. Medical history and laboratory data was recorded.
The mean HDL levels in Group 1 were 16.1 +/- 33 mg/dl compared to 74.9 +/- 12.6 mg/dl in Group 2. Using a multivariate logistic regression analysis, low HDL was inversely associated with death (OR 0.96, 95% 0.93-0.99, P = 0.02), 3.98 fold increase in odds of fever (OR 3.98, 95% CI 1.3-11.8, P = 0.01), and 6.7-fold increase in the risk of cancer (OR 6.68, 95% CI 1.8-24.5, P = 0.004). HDL serum levels were inversely associated with sepsis. For each 1 mg/dl increase in HDL, a relative 11% decrease in odds of sepsis was observed (OR 0.886, 95% CI 0.8-0.976, P = 0.01).
Extremely low serum HDL levels (< or =20 mg/dl) are associated with an increased risk of death, sepsis and malignancy.
高密度脂蛋白（HDL）作为一种抗动脉粥样硬化分子发挥着重要作用，同时还具有抗炎和抗血管生成特性。因此，研究了极低水平的HDL对败血症和恶性肿瘤风险的影响。
对在伊迪丝·沃尔夫森医疗中心住院的患者进行回顾性分析。患者分为两组：第1组：108例血清HDL水平≤20mg/dl的患者。第2组：96例血清HDL水平≥65mg/dl的患者。记录病史和实验室数据。
第1组的平均HDL水平为16.1±3.3mg/dl，而第2组为74.9±12.6mg/dl。使用多因素逻辑回归分析，低HDL与死亡呈负相关（比值比0.96，95%置信区间0.93 - 0.99，P = 0.02），发热几率增加3.98倍（比值比3.98，95%置信区间1.3 - 11.8，P = 0.01），癌症风险增加6.7倍（比值比6.68，95%置信区间1.8 - 24.5，P = 0.004）。HDL血清水平与败血症呈负相关。HDL每增加1mg/dl，败血症几率相对降低11%（比值比0.886，95%置信区间0.8 - 0.976，P = 0.01）。
极低的血清HDL水平（≤20mg/dl）与死亡、败血症和恶性肿瘤风险增加相关。
