Müller-Stöver Irmela, Verweij Jaco J, Hoppenheit Barbara, Göbels Klaus, Häussinger Dieter, Richter Joachim
Tropenmedizinische Ambulanz, Klinik für Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinikum Düsseldorf, Heinrich-Heine-Universität, Moorenstr. 5, 40225 Düsseldorf, Germany.
Parasitol Res. 2008 Feb;102(3):547-50. doi: 10.1007/s00436-007-0804-4. Epub 2007 Dec 2.
Plasmodium malariae is regarded as usually being susceptible to all anti-malarials whether applied for prophylaxis or treatment. We report on three cases of P. malariae infection which occurred 12-14 weeks after anti-malarial chemoprophylaxis or treatment with mefloquine or atovaquone/proguanil. The most likely explanation for the failure of mefloquine and atovaquone/proguanil to prevent quartan malaria occurring some months later is the insufficient effect on the particularly long-lasting pre-erythrocytic development stages of P. malariae.
间日疟原虫通常被认为对所有用于预防或治疗的抗疟药敏感。我们报告了3例间日疟原虫感染病例，这些病例发生在使用甲氟喹或阿托伐醌/氯胍进行抗疟化学预防或治疗后的12 - 14周。甲氟喹和阿托伐醌/氯胍未能预防数月后发生的三日疟最可能的解释是，它们对间日疟原虫特别持久的红细胞前期发育阶段的作用不足。
