Ghesquiere Sophie L, Castelain Els G, Spiessens Carl, Meuleman Christel L, D'Hooghe Thomas M
Department of Obstetrics and Gynecology, Leuven University Fertility Center, Leuven, Belgium.
Am J Obstet Gynecol. 2007 Dec;197(6):589.e1-5. doi: 10.1016/j.ajog.2007.05.016.
The goal of this study was to determine the relationship between the number of mature ovarian follicles and the (multiple) live birth rate after controlled ovarian hyperstimulation and intrauterine insemination.
A total of 2463 intrauterine insemination cycles performed during a natural cycle (n = 118), or after controlled ovarian hyperstimulation with either clomiphene citrate (n = 663) or with gonadotrophins (n = 1682) were reviewed to assess the impact of the type of stimulation and the number of follicles 14 mm or larger on the (multiple) live birth rate per cycle.
The live birth rate after intrauterine insemination was significantly higher (P = .02) after stimulation with gonadotrophins (13%) than after clomiphene cirate (8%) if only 1 follicle 14 mm or larger was present. If 2 or more follicles were present, there was no statistically significant difference between both stimulation methods.
Treatment of intrauterine insemination with gonadotrophin is effective with an acceptable (multiple) live birth rate when 1 or 2 follicles 14 mm or larger are present.
本研究的目的是确定在控制性卵巢过度刺激和宫内人工授精后，成熟卵泡数量与（多胎）活产率之间的关系。
回顾了在自然周期（n = 118）期间或使用枸橼酸氯米芬（n = 663）或促性腺激素（n = 1682）进行控制性卵巢过度刺激后进行的总共2463个宫内人工授精周期，以评估刺激类型和14毫米或更大卵泡数量对每个周期（多胎）活产率的影响。
如果仅存在1个14毫米或更大的卵泡，使用促性腺激素刺激后宫内人工授精的活产率（13%）显著高于使用枸橼酸氯米芬后（8%）（P = 0.02）。如果存在2个或更多卵泡，则两种刺激方法之间没有统计学上的显著差异。
当存在1个或2个14毫米或更大的卵泡时，用促性腺激素治疗宫内人工授精有效，且（多胎）活产率可接受。
