Broggi Sara, Cattaneo Giovanni Mauro, Molinelli Silvia, Maggiulli Eleonora, Del Vecchio Antonella, Longobardi Barbara, Perna Lucia, Fazio Ferruccio, Calandrino Riccardo
Medical Physics, Scientific Institute San Raffaele, Milan, Italy.
Radiother Oncol. 2008 Feb;86(2):231-41. doi: 10.1016/j.radonc.2007.11.005. Epub 2007 Dec 3.
Image-guided helical tomotherapy (HT) is a new modality for delivering intensity modulated radiation therapy (IMRT) with helical irradiation: the slip ring continuously rotates while the couch moves into the bore. The radiation source (Linac, 6 MV) is collimated into a fan beam and modulated by means of a binary multileaf collimator (MLC). A xenon detector array, opposite the radiation source, allows a megavoltage-CT (MVCT) acquisition of patient images for set-up verification. The aim of this paper is to report the results of a two-year quality control (QC) program for the physical and dosimetric characterization of an HT unit installed at our Institute and clinically activated in November 2004, in order to monitor and verify the stability and the reliability of this promising radiation treatment unit.
Conventional Linac acceptance protocols (ATP) and QC protocols were adapted to HT with the addition of specific items reflecting important differences between the two irradiation modalities. QC tests can be summarized as: (a) mechanical and geometrical characterization of the system's components: evaluation of alignment among radiation source-gantry rotation plan-jaws-MLC-MVCT; (b) treatment beam configuration in static condition: depth dose curves (PDD) and profiles, output factors, output reproducibility and linearity; (c) dynamic component characterization: accuracy and reproducibility of MLC positioning; rotational output reproducibility and linearity, leaf latency, couch movement constancy; (d) gantry-couch and MLC-gantry synchronization; and (e) MVCT image quality. Peculiar periodicity specific tolerance and action levels were defined. Ionization chambers (Exradin A1SL 0.056 cc), films (XOmat-V/EDR2), water and solid water phantoms were used to perform quality assurance measurements.
Over a two-year period the final average output variation after possible beam output adjustment was -0.2+/-1% for the static condition and equal to 0+/-1% for the rotational condition: around 98% of the collected output data was within the action level compared to 94% if no beam output adjustment was considered. An average energy variation of -0.4+/-0.4% was found. The daily absolute dose verification of IMRT plans showed a dose reproducibility of -0.5+/-1.2% and -0.4+/-2.2%, for low and high dose gradient regions, respectively. Source-jaws-MLC and MVCT alignment results and jaw and leaf positioning accuracy were +/-1mm. Couch-gantry-MLC synchrony tests showed good stability level (<or= +/-2mm).
QC results indicated good reproducibility of all HT mechanical-dosimetric performance.
图像引导螺旋断层放射治疗(HT)是一种通过螺旋照射进行调强放射治疗(IMRT)的新方式:滑环在治疗床移入孔内时持续旋转。放射源(直线加速器,6MV)被准直成扇形束,并通过二元多叶准直器(MLC)进行调制。在放射源对面的氙探测器阵列可进行兆伏级CT(MVCT)患者图像采集以进行摆位验证。本文旨在报告一项为期两年的质量控制(QC)计划的结果,该计划针对安装在我院并于2004年11月投入临床使用的一台HT设备进行物理和剂量学特性分析,以监测和验证这一有前景的放射治疗设备的稳定性和可靠性。
传统直线加速器验收协议(ATP)和QC协议适用于HT,并增加了反映两种照射方式重要差异的特定项目。QC测试可总结为:(a)系统组件的机械和几何特性:评估放射源 - 机架旋转平面 - 准直器 - MLC - MVCT之间的对准情况;(b)静态条件下的治疗束配置:深度剂量曲线(PDD)和剂量分布、输出因子、输出重复性和线性;(c)动态组件特性:MLC定位的准确性和重复性;旋转输出重复性和线性、叶片延迟、治疗床运动稳定性;(d)机架 - 治疗床和MLC - 机架同步性;以及(e)MVCT图像质量。定义了特殊的周期性特定公差和行动水平。使用电离室(Exradin A1SL 0.056cc)、胶片(XOmat - V/EDR2)、水和固体水模体进行质量保证测量。
在两年期间,经过可能的束输出调整后,静态条件下最终平均输出变化为 - 0.2±1%,旋转条件下为0±1%:与不考虑束输出调整时的94%相比,约98%的采集输出数据在行动水平范围内。发现平均能量变化为 - 0.4±0.4%。IMRT计划的每日绝对剂量验证显示,低剂量梯度区域和高剂量梯度区域的剂量重复性分别为 - 0.5±1.2%和 - 0.4±2.2%。源 - 准直器 - MLC和MVCT对准结果以及准直器和叶片定位精度为±1mm。治疗床 - 机架 - MLC同步测试显示稳定性良好(≤±2mm)。
QC结果表明所有HT机械 - 剂量学性能具有良好的重复性。