Soong T Rinda, Barouch Lili A, Champion Hunter C, Wigley Frederick M, Halushka Marc K
Department of Pathology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
Hum Pathol. 2007 Dec;38(12):1858-63. doi: 10.1016/j.humpath.2007.06.013.
Hydroxychloroquine- or chloroquine -induced cardiomyopathy is a rare but potentially fatal condition. Hydroxychloroquine and chloroquine are often used for long-term treatment of rheumatic diseases and for malaria prophylaxis. Hydroxychloroquine- and chloroquine-induced cardiomyopathy have well-described microscopic features, with the classic electron microscopic findings of myelin figures (myeloid bodies). We report on 2 new cases with novel findings. The first case, in a patient with systemic lupus erythematosus, was found to have megamitochondria in addition to myelin figures seen by electron microscopy. The second report describes the first case of hydroxychloroquine cardiomyopathy described in a patient with scleroderma. These novel findings will add to the present knowledge of hydroxychloroquine-induced cardiomyopathy in its pathology and its implication for treatment of rheumatic diseases.
羟氯喹或氯喹诱发的心肌病是一种罕见但可能致命的病症。羟氯喹和氯喹常用于长期治疗风湿性疾病及预防疟疾。羟氯喹和氯喹诱发的心肌病具有明确的微观特征，典型的电子显微镜下表现为髓鞘样结构（髓样小体）。我们报告了2例有新发现的病例。第一例是一名系统性红斑狼疮患者，除电子显微镜下可见的髓鞘样结构外，还发现有巨型线粒体。第二篇报告描述了第一例硬皮病患者中出现的羟氯喹心肌病病例。这些新发现将增进我们目前对羟氯喹诱发心肌病的病理学及其对风湿性疾病治疗影响的认识。
