Aqil Mohammed, Ahad Abdul, Sultana Yasmin, Ali Asgar
Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India.
Drug Discov Today. 2007 Dec;12(23-24):1061-7. doi: 10.1016/j.drudis.2007.09.001. Epub 2007 Oct 17.
Since its introduction, transdermal drug delivery has promised much but, in some respects has still to deliver on that initial promise, due to inherent limitations imposed by the percutaneous route. The greatest obstacle for transdermal delivery is the barrier property of the stratum corneum. Many approaches have been employed to breach the skin barrier, of which, the most widely used one is that of chemical penetration enhancers. Of the penetration enhancers, terpenes are arguably the most highly advanced and proven category and are classified as generally regarded as safe (GRAS) by the Food and Drug Administration. This paper presents an overview of the investigations on the feasibility and application of terpenes as sorption promoters for improved delivery of drugs through skin.
自经皮给药技术问世以来，它虽带来了诸多期望，但在某些方面，由于经皮途径存在的固有局限性，仍未完全实现最初的承诺。经皮给药的最大障碍是角质层的屏障特性。人们采用了许多方法来突破皮肤屏障，其中应用最广泛的是化学渗透促进剂。在渗透促进剂中，萜类化合物可以说是最先进且经过验证的类别，并且被美国食品药品监督管理局归类为一般认为安全（GRAS）。本文概述了关于萜类化合物作为吸附促进剂以改善药物经皮递送的可行性及应用的研究。
