Adamiak-Giera Urszula, Nowak Anna, Duchnik Wiktoria, Ossowicz-Rupniewska Paula, Czerkawska Anna, Machoy-Mokrzyńska Anna, Sulikowski Tadeusz, Kucharski Łukasz, Białecka Marta, Klimowicz Adam, Białecka Monika
Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Department of Cosmetic and Pharmaceutical Chemistry, Pomeranian Medical University, Szczecin, Poland.
Front Pharmacol. 2023 May 31;14:1157977. doi: 10.3389/fphar.2023.1157977. eCollection 2023.
In the treatment of pain, especially chronic pain, the rule of multimodal therapy applies, based on various painkillers mechanisms of action. The aim of the conducted study was to evaluate the penetration of ketoprofen (KET) and lidocaine hydrochloride (LH) through the human skin from a vehicle with transdermal properties. The results obtained with the use of the Franz chamber showed statistically significantly higher penetration of KET from the transdermal vehicle as compared to commercial preparations. It was also shown that the addition of LH to the transdermal vehicle did not change the amount of KET permeated. The study also compared the penetration of KET and LH by adding various excipients to the transdermal vehicle. Comparing the cumulative mass of KET that penetrated after the 24-h study, it was observed that the significantly highest permeation was found for the vehicle containing additionally Tinctura capsici, then for that containing camphor and ethanol, and the vehicle containing menthol and ethanol as compared to that containing Pentravan alone. A similar tendency was observed in the case of LH, where the addition of Tinctura capsici, menthol and camphor led to a statistically significant higher penetration. Adding certain drugs such as KET and LH to Pentravan, and substances such as menthol, camphor or capsaicin, can be an interesting alternative to administered enteral drugs especially in the group of patients with multiple diseases and polypragmasy.
在疼痛治疗中，尤其是慢性疼痛，基于各种止痛药的作用机制，多模式治疗原则适用。本研究的目的是评估酮洛芬（KET）和盐酸利多卡因（LH）从具有透皮特性的载体透过人体皮肤的渗透情况。使用弗兰兹扩散池获得的结果显示，与市售制剂相比，KET从透皮载体的渗透在统计学上显著更高。还表明，向透皮载体中添加LH不会改变KET的渗透量。该研究还通过向透皮载体中添加各种辅料来比较KET和LH的渗透情况。比较24小时研究后渗透的KET的累积质量，观察到含有辣椒酊的载体的渗透量显著最高，其次是含有樟脑和乙醇的载体，以及含有薄荷醇和乙醇的载体，与仅含有Pentravan的载体相比。在LH的情况下也观察到类似趋势，添加辣椒酊、薄荷醇和樟脑导致渗透在统计学上显著更高。将某些药物如KET和LH添加到Pentravan中，以及添加薄荷醇、樟脑或辣椒素等物质，对于尤其是患有多种疾病和多种药物并用的患者群体来说，可能是口服给药的一个有趣替代方案。
