Miliauskaite Asta, Selimovic Denis, Hannig Matthias
Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University Hospitals, Homburg/Saar, Germany.
J Periodontol. 2007 Oct;78(10):2043-50. doi: 10.1902/jop.2007.060492.
This case report presents a new treatment for localized aggressive periodontitis using surgery (papilla preservation technique [PPT]) combined with enamel matrix proteins and bioactive glass.
Eight intrabony defects in a 19-year-old woman with localized aggressive periodontitis were treated by PPT and the application of enamel matrix proteins or enamel matrix proteins in combination with bioactive glass. Probing depth, gingival recession, and clinical attachment level (CAL) were evaluated at baseline, 6 and 12 months, and 2 and 3 years after treatment. The primary outcome variable was CAL.
After 3 years, the sites treated with enamel matrix proteins demonstrated a mean CAL change from 8.3 +/- 3.2 mm to 4.0 +/- 3.6 mm (P < 0.39), and the sites treated with enamel matrix proteins combined with bioactive glass showed a mean CAL change from 8.6 +/- 2.4 mm to 3.7 +/- 0.8 mm (P < 0.001).
In the present case of aggressive periodontitis, application of enamel matrix proteins with or without the addition of bioactive glass resulted in the successful treatment of intrabony defects.
本病例报告介绍了一种治疗局限性侵袭性牙周炎的新方法，即采用手术（乳头保留技术[PPT]）联合釉基质蛋白和生物活性玻璃。
对一名患有局限性侵袭性牙周炎的19岁女性的8个骨内缺损采用PPT并应用釉基质蛋白或釉基质蛋白联合生物活性玻璃进行治疗。在基线、治疗后6个月和12个月以及2年和3年时评估探诊深度、牙龈退缩和临床附着水平（CAL）。主要结局变量为CAL。
3年后，用釉基质蛋白治疗的部位CAL平均变化从8.3±3.2毫米变为4.0±3.6毫米（P<0.39），用釉基质蛋白联合生物活性玻璃治疗的部位CAL平均变化从8.6±2.4毫米变为3.7±0.8毫米（P<0.001）。
在本侵袭性牙周炎病例中，应用釉基质蛋白加或不加生物活性玻璃均成功治疗了骨内缺损。
