Artzi Zvi, Sudri Shiran, Platner Ori, Kozlovsky Avital
Department of Periodontology and Oral Implantology, Tel Aviv University, Tel Aviv-Yafo 69979, Israel.
Dent J (Basel). 2019 Mar 8;7(1):29. doi: 10.3390/dj7010029.
The purpose of this study is to evaluate and compare, retrospectively, the outcome of two different periodontal regeneration procedures in patients suffering from aggressive periodontitis (AgP). Twenty-eight patients were diagnosed with AgP, suffering from several intra-bony defects (IBD); that were treated by one of two periodontal regeneration techniques randomly assigned to each patient: a. guided tissue regeneration (GTR) or b. an application of extracted enamel matrix derivatives (EMD) combined with demineralized bone xenograft particles (DBX). Probing pocket depth (PPD), clinical attachment level (CAL), and gingival recession were recorded. Pre-treatment and follow-up (up to 10 years from the surgery) recordings were analyzed statistically within and between groups. A significant reduction was shown at time on PPD and CAL values, however, not between subject groups. CAL values decreased in all sites. At the EMD group (44 sites), CAL gain was 1.92 mm (±1.68) from pre-treatment to follow-up (p < 0.001) and at the GTR group (12 sites) CAL gain of 2.27 (±1.82) mm. In conclusion, 1⁻10 years observations have shown that surgical treatment of AgP patients by either GTR or by application of EMD/DBX results in similar successful clinical results.
本研究的目的是回顾性评估和比较侵袭性牙周炎（AgP）患者两种不同牙周再生手术的效果。28例被诊断为AgP且患有多个骨内缺损（IBD）的患者，被随机分配接受以下两种牙周再生技术之一的治疗：a. 引导组织再生（GTR）；b. 应用提取的釉基质衍生物（EMD）联合脱矿骨异种移植颗粒（DBX）。记录探诊深度（PPD）、临床附着水平（CAL）和牙龈退缩情况。对治疗前和随访（手术至长达10年）记录进行组内和组间统计学分析。PPD和CAL值在随访时均显著降低，但不同治疗组间无差异。所有部位的CAL值均下降。在EMD组（44个部位），从治疗前到随访时CAL增加了1.92 mm（±1.68）（p < 0.001），在GTR组（12个部位）CAL增加了2.27（±1.82）mm。总之，1至10年的观察表明，GTR或应用EMD/DBX对AgP患者进行手术治疗均能取得相似的成功临床效果。
