Huang Chin-Chang
Department of Neurology, Chang Gung Memorial Hospital, Taipei, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Chang Gung Med J. 2007 Sep-Oct;30(5):385-95.
Excessive manganese exposure may induce a neurological syndrome called manganism, which is similar to Parkinson's disease (PD). However, close observation of patients with manganism reveals a clinical disease entity different from PD, not only in the clinical manifestations, but also in therapeutic responses, in neuroimaging studies such as magnetic resonance imaging, positron emission tomography and dopamine transporter images, and in the neuropathological findings. Furthermore, after long-term follow-up studies, patients with manganism showed prominent deterioration in the parkinsonian symptoms during the initial 5-10 years, followed by a plateau during the following 10 years, which is also different from the clinical course of patients with PD. Although typical patients with manganism are different from patients with PD, the potential risk of inhaling welding fumes, which may accelerate the onset of PD or even induce PD, has been raised during recent years. This controversial topic requires further investigation.
过量接触锰可能会引发一种名为锰中毒的神经综合征，它与帕金森病（PD）相似。然而，对锰中毒患者的密切观察发现，这是一种与帕金森病不同的临床疾病实体，不仅在临床表现上不同，在治疗反应、磁共振成像、正电子发射断层扫描和多巴胺转运体成像等神经影像学研究以及神经病理学发现方面也有所不同。此外，经过长期随访研究，锰中毒患者在最初的5至10年里帕金森症状显著恶化，随后的10年则处于平稳期，这也与帕金森病患者的临床病程不同。尽管典型的锰中毒患者与帕金森病患者不同，但近年来，吸入焊接烟雾可能加速帕金森病发病甚至诱发帕金森病的潜在风险已被提出。这个有争议的话题需要进一步研究。
