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宫腔粘连综合征的宫腔镜治疗

Hystroscopic management of Ashermans syndrome.

作者信息

Yasmin Haleema, Nasir Ayesha, Noorani Khurshid J

机构信息

Department of Obstetrics and Gynaecology, Jinnah Postgraduate Medical Centre, Karachi.

出版信息

J Pak Med Assoc. 2007 Nov;57(11):553-5.

Abstract

OBJECTIVE

To confirm the diagnosis of Asherman's syndrome in patients with scanty menses/amenorrhoea or infertility and to assess the effectiveness of hysteroscopy in the treatment of Asherman's syndrome.

METHODS

A hospital based descriptive study conducted on 20 patients presenting with amenorrhoea, oligomenorrhoea, or infertility from Jan 2004 to June 2005. They were selected after excluding hormonal imbalances, premature ovarian failure and congenital uterine abnormalities. All patients underwent diagnostic hysteroscopy and resection of adhesions. Specimens were sent for Histopathology and bacterial culture.

RESULT

A total of 20 patients were included in this study, the median age was 26 years, 65% had presented with scanty menses with secondary infertility, 20% with secondary ammenorrhoea, and 15% with primary infertility alone. Hysteroscopic findings showed thick fibrous adhesions in 45% patients, 40% had flimsy adhesions and 15% had muscular adhesions. It was seen that 65% had adhesions in the body of uterus, 25% at the site of internal os and 1% had adhesions in the cervical canal as well as the body of the uterus. Normal menstrual cycle was resumed in 95% patients, whereas two patients conceived and were followed to term. Dense fibrous tissue with few patches of calcification and no signs of secretory or proliferative cells was found in 35% patients. In 45% endometrium showed proliferative changes and collagen fibers. Only 1 patient had a positive AFB culture and the histopathology showed few graulomas with epitheloid cells most of the tissue replaced by necrotic tissue with patchy areas of caseation.

CONCLUSION

Hysteroscopy is an effective procedure for not only diagnosing Ashermans Syndrome, but is equally effective for treating it..

摘要

目的

确诊月经过少/闭经或不孕患者的阿谢曼综合征,并评估宫腔镜检查治疗阿谢曼综合征的有效性。

方法

2004年1月至2005年6月,对20例闭经、月经过少或不孕患者进行了一项基于医院的描述性研究。排除激素失衡、卵巢早衰和先天性子宫异常后选取这些患者。所有患者均接受诊断性宫腔镜检查及粘连切除术。标本送组织病理学检查和细菌培养。

结果

本研究共纳入20例患者,中位年龄为26岁,65%表现为月经过少伴继发性不孕,20%为继发性闭经,15%仅为原发性不孕。宫腔镜检查结果显示,45%的患者有致密纤维粘连,40%有薄弱粘连,15%有肌性粘连。可见65%的患者子宫体有粘连,25%在宫颈内口处有粘连,1%在宫颈管及子宫体均有粘连。95%的患者月经周期恢复正常,2例患者受孕并足月分娩。35%的患者发现致密纤维组织,有少量钙化斑,无分泌或增殖细胞迹象。45%的患者子宫内膜显示增殖性改变及胶原纤维。仅1例患者抗酸杆菌培养阳性,组织病理学显示有少量含上皮样细胞的肉芽肿,大部分组织被坏死组织及片状干酪样变取代。

结论

宫腔镜检查不仅是诊断阿谢曼综合征的有效方法,治疗该综合征同样有效。

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