Changes in Kaposi's sarcoma induced by dapsone.

The authors describe the clinical and histological changes in well-established classic Kaposi's sarcoma lesions during 2-years therapy with dapsone. Both the patients noted a great improvement in their symptoms. Clinical examination did not show significant modifications of the lesions. Histology showed a striking reduction in the spindle-cell component and an increase in the number of mature vessels. Immunohistochemistry with an endothelial cell marker (FVIIIRAg) confirmed the presence of an increased number of mature vessels after treatment. This study seems to confirm that dapsone can modify well-established lesions of classic Kaposi's sarcoma.