Martínez-Ramos Federico, Salgado-Zamora Hector, Campos-Aldrete Maria Elena, Melendez-Camargo Estela, Márquez-Flores Yazmín, Soriano-García Manuel
Departamento de Química Inorgánica, Escuela Nacional de Ciencias Biológicas, IPN Prolongación de Carpio y Plan de Ayala S/N, México DF, Mexico.
Eur J Med Chem. 2008 Jul;43(7):1432-7. doi: 10.1016/j.ejmech.2007.09.029. Epub 2007 Oct 10.
The alkylation reaction of 2,2'-diseleno and 4,4'-diseleno-bis(benzoic acid) derivatives in the presence of sodium borohydride and alkyl halides allowed the synthesis of various new o- and p-alkylselenenylated benzoic acid derivatives in good yields. The anti-inflammatory activity of selected selenide derivatives on granuloma induced by subcutaneous implantation of cotton pellets in Wistar rats was examined. Selenium derivatives 2a, 2c and 2e showed anti-inflammatory activity although to a lesser extent as compared to indomethacin, however they were found less toxic than the latter.
在硼氢化钠和卤代烃存在的情况下，2,2'-二硒基和4,4'-二硒基双（苯甲酸）衍生物的烷基化反应能够以良好的产率合成各种新型的邻位和对位烷基硒基苯甲酸衍生物。考察了所选硒化物衍生物对Wistar大鼠皮下植入棉球诱导的肉芽肿的抗炎活性。硒衍生物2a、2c和2e表现出抗炎活性，尽管与吲哚美辛相比程度较小，然而发现它们的毒性比后者小。
