Marin Keith, Oleszewski Karen, Muehlbauer Paula
The National Institutes of Health, Bethesda, MD.
Clin J Oncol Nurs. 2007 Dec;11(6):881-9. doi: 10.1188/CJON.07.881-889.
The National Cancer Institute (NCI) announced in January 2006 the use of intraperitoneal (IP) combined with IV chemotherapy postoperatively as the preferred treatment method for advanced ovarian cancer. The announcement stimulated the need for oncology nurses to become familiar with IP chemotherapy administration and patient management guidelines. IP administration allows a high concentration of chemotherapy to come into direct contact with tumors and surrounding tissues and organs. IP chemotherapy also is administered in clinical trials and some clinical settings for other histologies, such as low-grade gastrointestinal carcinoma and appendiceal carcinoma, which tend to spread locally before invading the bloodstream. Local-regional chemotherapy potentially is an ideal treatment for local spread of those peritoneal carcinomas. Overall side effects from regional treatment are less severe than with systemic treatment. Oncology nurses can help minimize and alleviate discomfort associated with IP chemotherapy administration. This article focuses on nursing management strategies for patients receiving IP chemotherapy for ovarian cancer and other peritoneal carcinomatosis.
美国国立癌症研究所（NCI）于2006年1月宣布，术后采用腹腔内（IP）联合静脉化疗作为晚期卵巢癌的首选治疗方法。这一宣布激发了肿瘤护理人员熟悉腹腔内化疗给药及患者管理指南的需求。腹腔内给药可使高浓度化疗药物直接接触肿瘤及周围组织和器官。腹腔内化疗也用于其他组织学类型肿瘤的临床试验及一些临床治疗，如低级别胃肠道癌和阑尾癌，这些肿瘤往往在侵入血流之前先发生局部扩散。局部区域化疗可能是这些腹膜癌局部扩散的理想治疗方法。区域治疗的总体副作用比全身治疗轻。肿瘤护理人员可帮助将腹腔内化疗给药相关的不适降至最低并减轻不适。本文重点关注接受腹腔内化疗治疗卵巢癌及其他腹膜转移癌患者的护理管理策略。
