精神分裂症中的易感性标志物。
Markers of vulnerability in schizophrenia.
作者信息
Ladea Maria, Prelipceanu Dan
机构信息
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
出版信息
J Med Life. 2009 Apr-Jun;2(2):155-64.
Abstract
Vulnerability in schizophrenia is an integrative concept, which tries to explain the development of schizophrenia as an interaction between different individual susceptibility factors and environmental risk factors. Vulnerability markers used in genetic studies include biochemical indicators, neuroanatomical, neurophysiologic, and cognitive abnormalities. Among those, the most extensive studied markers were: evoked potentials, smooth pursuit eye movements, and attentional deficits. Some of the potential indicators presented in this paper satisfy most of the criteria necessary for a vulnerability marker, but none meets all of them. Nevertheless, they represent important markers of risk to schizophrenia.
摘要
精神分裂症的易感性是一个综合概念，它试图将精神分裂症的发展解释为不同个体易感性因素与环境危险因素之间的相互作用。基因研究中使用的易感性标记包括生化指标、神经解剖学、神经生理学和认知异常。其中，研究最为广泛的标记有：诱发电位、平稳跟踪眼球运动和注意力缺陷。本文中提出的一些潜在指标满足了作为易感性标记所需的大部分标准，但没有一个指标能满足所有标准。尽管如此，它们仍是精神分裂症重要的风险标记。
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