使用工作暴露矩阵对工人职业体力活动与前列腺癌进行巢式病例对照研究。
Nested case-control study of occupational physical activity and prostate cancer among workers using a job exposure matrix.
作者信息
Krishnadasan Anusha, Kennedy Nola, Zhao Yingxu, Morgenstern Hal, Ritz Beate
机构信息
Department of Epidemiology, School of Public Health, University of California-Los Angeles, CA, USA.
出版信息
Cancer Causes Control. 2008 Feb;19(1):107-14. doi: 10.1007/s10552-007-9076-7. Epub 2007 Dec 7.
OBJECTIVE
We conducted a nested case-control study of 362 cases diagnosed between 1 January 1988 and 31 December 1999, and 1,805 matched controls to examine the association between occupational physical activity and prostate-cancer incidence among workers at a nuclear and rocket engine-testing facility in Southern California.
METHODS
We obtained cancer incidence data from the California Cancer Registry and seven other state cancer registries. Data from company records were used to construct a job exposure matrix (JEM) for occupational physical activity during employment. Conditional logistic regression was used to estimate associations.
RESULTS
With adjustment for occupational confounders, including socioeconomic status and trichloroethylene (TCE) exposure, high activity levels at work were inversely associated with prostate-cancer incidence among aerospace workers (odds ratio [OR] = 0.55; 95% CI = 0.32-0.95), but not among radiation workers (OR = 0.95; 95% CI = 0.43-2.1).
CONCLUSIONS
Our results suggest that adult men who are more continually active at work may have a decreased risk of prostate cancer.
目的
我们进行了一项巢式病例对照研究，研究对象为1988年1月1日至1999年12月31日期间确诊的362例病例以及1805例匹配对照，以研究南加州一家核与火箭发动机测试机构的工人职业体力活动与前列腺癌发病率之间的关联。
方法
我们从加利福尼亚癌症登记处及其他七个州的癌症登记处获取癌症发病率数据。利用公司记录中的数据构建了一份就业期间职业体力活动的工作暴露矩阵（JEM）。采用条件逻辑回归来估计关联。
结果
在对包括社会经济地位和三氯乙烯（TCE）暴露等职业混杂因素进行调整后，工作中高活动水平与航空航天工人的前列腺癌发病率呈负相关（优势比[OR]=0.55；95%置信区间[CI]=0.32 - 0.95），但与放射工人无关（OR = 0.95；95% CI = 0.43 - 2.1）。
结论
我们的结果表明，工作中持续体力活动较多的成年男性患前列腺癌的风险可能降低。
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