[通过体育活动预防前列腺癌的流行病学证据]
[Epidemiological evidence for preventing prostate cancer by physical activity].
作者信息
Heitkamp Hans-Christian, Jelas Ivan
机构信息
Abteilung Sportmedizin, Medizinische Klinik, Universitätsklinikum Tübingen, Silcherstr. 5, 72076, Tübingen, Deutschland.
出版信息
Wien Med Wochenschr. 2012 Dec;162(23-24):533-40. doi: 10.1007/s10354-012-0121-0. Epub 2012 Oct 12.
BACKGROUND
Earlier reviews yielded contradictory results for reducing the risk of prostate cancer by physical activity.
METHODS
32 Cohort studies and 17 case control studies taking the ones up to 2001 and the ones up to 2010 together. Additionally, subgroups from studies analyzing aggressive carcinomas and those after the age of 65 were presented separately.
RESULTS
In the mean, no risk reduction was found in earlier and in studies from the last 8 years with mostly imprecisely measured activity. In 7 studies with subgroups on aggressive forms a positive dose response relationship was documented, being significant in 3 studies. The subgroup over 65 years with high amount of physical activity yielded a significant effect in 3 studies.
CONCLUSIONS
Physical activity in leisure and in work fails to be protective but substantial evidence exists for an effective prevention by intensive physical activity.
背景
早期的综述对于通过体育活动降低前列腺癌风险得出了相互矛盾的结果。
方法
32项队列研究和17项病例对照研究，将截至2001年的研究和截至2010年的研究汇总在一起。此外，分别呈现了分析侵袭性癌的研究亚组以及65岁以上人群的研究亚组。
结果
总体而言，在早期研究以及过去8年中大多活动测量不准确的研究中，未发现风险降低。在7项有侵袭性癌亚组的研究中，记录到了正剂量反应关系，其中3项研究具有显著性。65岁以上且体育活动量高的亚组在三项研究中产生了显著效果。
结论
休闲和工作中的体育活动并无保护作用，但有大量证据表明高强度体育活动可有效预防。
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