Granados Rosario, Aramburu José Antonio, Rodríguez José María, Nieto María Antonia
Department of Pathology, Hospital Universitario de Getafe, Madrid, Spain.
Diagn Cytopathol. 2008 Jan;36(1):42-6. doi: 10.1002/dc.20744.
Follicular dendritic cell (FDC) sarcoma is an exceedingly uncommon tumor of lymph nodes and extranodal tissues. The inflammatory pseudotumor (IPT)-like variant of FDC sarcoma of intraabdominal location is considered a separate entity, with different clinical and pathological features than those of the classic FDC tumor. There have been only 12 cytological reports of FDC sarcomas in the literature. Two of them were metastases to the liver and, like our case, had features of IPT. Fine-needle aspiration biopsy (FNAB) and imprint and scrape cytology from the surgically excised tumor here reported revealed spindle tumor cells with moderate pleomorphism, nuclear grooves, prominent nucleoli, and cytoplasmic processes, admixed with inflammatory cells. To the best of our knowledge, this is the first cytology report of a primary hepatic FDC tumor. The cytological findings permit the recognition of this tumor. However, confirmation by inmunohistochemistry (IHQ) is mandatory for a definitive diagnosis.
滤泡性树突状细胞（FDC）肉瘤是一种极其罕见的淋巴结和结外组织肿瘤。腹腔内FDC肉瘤的炎性假瘤（IPT）样变体被认为是一个独立的实体，具有与经典FDC肿瘤不同的临床和病理特征。文献中仅有12例FDC肉瘤的细胞学报告。其中2例为肝转移，与我们的病例一样，具有IPT的特征。本文报道的经手术切除肿瘤的细针穿刺活检（FNAB）以及印片和刮片细胞学检查显示，梭形肿瘤细胞具有中度多形性、核沟、显著核仁及胞质突起，并混有炎性细胞。据我们所知，这是原发性肝FDC肿瘤的首例细胞学报告。细胞学检查结果有助于识别该肿瘤。然而，明确诊断必须通过免疫组织化学（IHQ）进行确认。
