Howland John G, Harrison Rebecca A, Hannesson Darren K, Phillips Anthony G
Department of Medicine, University of British Columbia, Vancouver, Canada.
Hippocampus. 2008;18(3):251-7. doi: 10.1002/hipo.20396.
The hippocampus is critical for spatial memory. Recently, subregional differences in the function of hippocampus have been described in a number of behavioral tasks. The present experiments assessed the effects of reversibly lesioning either the dorsal (dHip) or ventral hippocampus (vHip) on spontaneous tests of spatial recognition and temporal order memory. We report that although the dHip is necessary for spatial recognition memory (RM) (distinguishing a novel from a familiar spatial location), the vHip is involved in temporal order memory (the capacity to distinguish between two spatial locations visited at different points in time), but not RM. These findings and others are consistent with the hypothesis that temporal order memory is supported by an integrated circuit of limbic areas including the vHip and the medial prefrontal cortex.
海马体对空间记忆至关重要。最近，在许多行为任务中已经描述了海马体功能的亚区域差异。本实验评估了可逆性损伤背侧海马体（dHip）或腹侧海马体（vHip）对空间识别和时间顺序记忆自发测试的影响。我们报告称，虽然dHip对空间识别记忆（RM）（区分新的和熟悉的空间位置）是必需的，但vHip参与时间顺序记忆（区分在不同时间点访问的两个空间位置的能力），而不参与RM。这些发现以及其他发现与以下假设一致，即时间顺序记忆由包括vHip和内侧前额叶皮质在内的边缘区域的整合回路支持。
