Christiansen J S, Jørgensen J O, Pedersen S A, Müller J, Jørgensen J, Møller J, Heickendorf L, Skakkebaek N E
University Department of Endocrinology, Aarhus Kommunehospital, Denmark.
Horm Res. 1991;36 Suppl 1:66-72. doi: 10.1159/000182192.
Growth hormone (GH) deficiency in adults, whether GH deficient since childhood or patients rendered GH deficient in adult life, is associated with psychosocial maladjustment, reduced muscle strength and reduced exercise capacity. Body composition is significantly altered with increased fat and decreased muscle volume as compared to healthy subjects. Kidney function is subnormal, and so is sweat secretion. Epidemiological data suggest premature mortality due to cardiovascular disease in hypopituitary patients. Short-term GH treatment trials have shown improved psychosocial performance, normalization of body composition, increased muscle strength, improved exercise capacity, increased cardiac performance and increase in bone mineral mass as well as in serum markers of bone turnover, and normalization of kidney function. Thus GH replacement therapy in GH-deficient adults exhibits potential long-term beneficial effects. A number of important questions has to be addressed before long-term GH replacement therapy in GH-deficient adults can be considered on a routine basis.
成人生长激素（GH）缺乏症，无论是自儿童期起就缺乏GH，还是在成年后导致GH缺乏的患者，都与心理社会适应不良、肌肉力量下降和运动能力降低有关。与健康受试者相比，身体成分发生显著改变，脂肪增加而肌肉量减少。肾功能不正常，汗液分泌也不正常。流行病学数据表明垂体功能减退患者因心血管疾病过早死亡。短期GH治疗试验显示，心理社会表现得到改善，身体成分正常化，肌肉力量增加，运动能力提高，心脏功能增强，骨矿物质质量以及骨转换血清标志物增加，肾功能恢复正常。因此，对GH缺乏的成年人进行GH替代治疗具有潜在的长期有益效果。在可以常规考虑对GH缺乏的成年人进行长期GH替代治疗之前，必须解决一些重要问题。
