Khonicheva N M, Livanova L M, Tsykunov S G, Osipova T A, Loriia M V, Elbakidze A G, Tikhonov V P, Aĭrapetiants M G
Zh Vyssh Nerv Deiat Im I P Pavlova. 2007 Sep-Oct;57(5):591-7.
After preliminary testing on a multiparameter scale, test and experimental groups of Wistar male rats were formed on the principle of identical distribution of individuals with different anxiety levels. A negative Spearman correlation between the testosterone blood concentration and the level of anxiety was observed in intact rats: the minimum hormonal concentrations (lower than 5 nmol/l) were found in rats with high anxiety, whereas the maximum concentrations (up to 16 nmol/l) corresponded to the higher anxiety level (prevalence of passive defense reactions during testing). After a sort-term exposure to life-threatening situation (viewing of a boa's attacking and devouring two victim rats from the test group), the correlation was deranged because of appearance of a scatter in testosterone blood concentration (from 3 to 21 nmol/l) in rats with low anxiety. Neurotization with inescapable pain stimulation also deranged the initial anxiety-testosterone correlation, but, as distinct from the exposure to life-threatening situation, eliminated individual differences in testosterone concentration at its low level. The results suggest the existence of multiple ways of adaptation to life-threatening situations in a rat population.
在多参数量表上进行初步测试后，按照焦虑水平不同个体分布相同的原则，组建了Wistar雄性大鼠的测试组和实验组。在未受干扰的大鼠中，观察到血液中睾酮浓度与焦虑水平之间存在负Spearman相关性：高焦虑大鼠的激素浓度最低（低于5 nmol/l），而最高浓度（高达16 nmol/l）对应较高的焦虑水平（测试期间被动防御反应占主导）。在短期暴露于危及生命的情境（观看一条蟒蛇攻击并吞食实验组的两只受害大鼠）后，相关性紊乱，因为低焦虑大鼠的血液睾酮浓度出现了离散（从3到21 nmol/l）。不可逃避的疼痛刺激导致的神经化也扰乱了最初的焦虑-睾酮相关性，但与暴露于危及生命的情境不同的是，它消除了低水平睾酮浓度的个体差异。结果表明，大鼠群体中存在多种适应危及生命情境的方式。
