Khonicheva N M, Livanova L M, Tsykunov S G, Osipova T A, Loriya M V, Elbakidze A G, Tikhonov V P, Airapetyants M G
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia.
Neurosci Behav Physiol. 2008 Nov;38(9):985-9. doi: 10.1007/s11055-008-9081-7. Epub 2008 Oct 31.
Studies of identical groups of male Wistar rats after preliminary selection to give groups including extreme behavioral types with low and high rankings on the anxiety scale showed that blood testosterone concentrations in intact rats (controls) correlated negatively with anxiety ranking, i.e., minimal hormone concentrations (no greater than 5 nM) corresponded to high levels of anxiety - with a predominance of passive defensive behavioral components on testing. Short-term exposure to a "death threat" situation (sight of a boa attacking and eating two individuals from the group of rats) impaired this correlational relationship in a manner comparable to the sequelae of chronic neuroticization by unavoidable pain stimulation. Impairments were manifest as scatter in measures in low-anxiety animals (3-21 nM). This characteristic, reflecting the multitude of adaptive pathways in the population in threat situations, distinguishes this type of action from neuroticization by unavoidable pain stimulation, which leveled out individual differences and decreased the hormone level.
对经过初步筛选的雄性Wistar大鼠同组进行研究，将其分为焦虑量表排名低和高的极端行为类型组，结果显示，未阉割大鼠（对照组）的血液睾酮浓度与焦虑排名呈负相关，即激素浓度最低时（不超过5 nM）对应着高度焦虑——测试时以被动防御行为成分为主。短期暴露于“死亡威胁”情境（看到一条蟒蛇攻击并吃掉大鼠组中的两只个体）会破坏这种相关关系，其方式类似于不可避免的疼痛刺激导致的慢性神经症化后遗症。这种破坏表现为低焦虑动物（3 - 21 nM）测量值的分散。这一特征反映了群体在威胁情境中的多种适应途径，将这种作用类型与不可避免的疼痛刺激导致的神经症化区分开来，后者消除了个体差异并降低了激素水平。
