Zhang Dandan, Cheng Maosheng, Hyun Myung Ho, Xiong Zhili, Pan Li, Li Famei
Department of Analytical Chemistry, Shenyang Pharmaceutical University, Shen-yang, China.
Pharmazie. 2007 Nov;62(11):836-40.
The enantiomeric resolution of six beta2-agonists including bambuterol, clenbuterol, clenproperol, fumoterol, mabuterol and terbutaline, was studied on three macrocyclic antibiotic chiral stationary phases (CSPs): Chirobiotic V, T and R. By varying the mobile phase compositions for different CSPs, all the six compounds were successfully separated on Chirobiotic V and T CSPs. The thermodynamic parameter variation was calculated. The chiral recognition mechanism was discussed, the ionic interaction was confirmed to be the most dramatic interaction responsible for the chiral recognition. No enantiosepartion for all the beta2-agonists was found on Chirobiotic R CSP.
研究了包括班布特罗、克仑特罗、氯丙那林、福莫特罗、马布特罗和特布他林在内的六种β2激动剂在三种大环抗生素手性固定相（CSPs）上的对映体拆分：Chirobiotic V、T和R。通过改变不同CSPs的流动相组成，所有六种化合物在Chirobiotic V和T CSPs上均成功分离。计算了热力学参数变化。对手性识别机制进行了讨论，证实离子相互作用是负责手性识别的最显著相互作用。在Chirobiotic R CSP上未发现所有β2激动剂的对映体分离。
