De Marinis L, Mancini A, Sciuto R, Calabrò F, Zuppi P, Fiumara C, Goglia A, Sofo L, Bellantone R, Crucitti F
Catholic University School of Medicine, Rome, Italy.
Minerva Endocrinol. 1991 Jul-Sep;16(3):107-11.
We report our experience in the clinical presentation and management of 12 patients with primary hyperparathyroidism, who underwent successful surgery. Comparing our results with those previously reported in the literature, we have attempted to correlate the kind of parathyroid lesion, the magnitude of hypercalcemia and PTH increase, and clinical symptoms. Often these relationships are intriguing; we have tried to classify our patients describing four groups, according to clinical and humoral findings: 1) patients with very mild hypercalcemia and aspecific symptoms; 2) patients with a finding of recurrent hypercalcemia and prevalent renal involvement; 3) patients with severe hypercalcemia, plurisystemic involvement and general decay; 4) patients with medical emergencies. Finally, some considerations on rare histological pictures (hyperfunctioning carcinoma, oxyphil cell adenoma) are reported.
我们报告了12例接受成功手术的原发性甲状旁腺功能亢进患者的临床表现及治疗经验。将我们的结果与先前文献报道的结果进行比较，我们试图将甲状旁腺病变类型、高钙血症和甲状旁腺激素升高的程度以及临床症状联系起来。这些关系往往很有趣；我们根据临床和体液检查结果将患者分为四组进行描述：1）血钙轻度升高且症状不具特异性的患者；2）血钙反复升高且以肾脏受累为主的患者；3）血钙严重升高、多系统受累且全身状况衰退的患者；4）有医疗急症的患者。最后，报告了一些关于罕见组织学表现（功能亢进性癌、嗜酸细胞腺瘤）的思考。
