Bratus' V V, Talaeva T V, Isaechkina I M, Tishkin S M, Sergienko O V, Taranenko V M
Patol Fiziol Eksp Ter. 1991 Sep-Oct(5):17-20.
Changes in the structure and functional properties of the vascular wall after 8 months of alimentary hypercholesterolemia (HCE) were studied. The experiments were conducted on the circular bands of the arch of the aorta in rabbits. Sharp inhibition of the reactivity of the vascular bands was established, which was associated first of all with thickening of the intima due to the development of fibro-atheromatous changes in it. At the same time, the smooth-muscle cells of the vascular wall maintained marked reactivity to various direct and receptor-mediated test effects. The functional significance of the endothelium in regulation of the vascular tonus, manifested by weakened endothelium-dependent relaxation, was sharply inhibited in the late stages of HCE. It is shown that reduction of the sensitivity of the smooth-muscle cells to the endothelium-dependent relaxation factor is the principal factor of weakening of the endothelium-dependent dilatational effects. After 8 months of HCE the aortic wall is capable of liberating a substance which is similar to the endothelium-dependent relaxation factor in its action, even when the thickened intima is completely removed.
研究了食饵性高胆固醇血症（HCE）8个月后血管壁结构和功能特性的变化。实验在兔主动脉弓的环形条带上进行。确定了血管条带反应性的急剧抑制，这首先与内膜增厚有关，内膜增厚是由于其中发生纤维粥样病变。同时，血管壁的平滑肌细胞对各种直接和受体介导的测试效应保持明显的反应性。在HCE后期，内皮在调节血管张力方面的功能意义（表现为内皮依赖性舒张减弱）受到急剧抑制。结果表明，平滑肌细胞对内皮依赖性舒张因子敏感性的降低是内皮依赖性扩张效应减弱的主要因素。HCE 8个月后，即使完全去除增厚的内膜，主动脉壁仍能够释放一种作用类似于内皮依赖性舒张因子的物质。
