Taranenko V M, Tishkin S M, Talaeva T V, Isaechkina I M, Bratus' V V
Patol Fiziol Eksp Ter. 1991 Jan-Feb(1):5-7.
The authors studied the effect of various calcium antagonists--verapamil (VP) and Mg2+ (MgCl2) on the character of affection of the vascular wall ulcer conditions of prolonged hypercholesterolemia (HCE). The blood cholesterol (CS) content increased by the end of the 8th month of HCE to eight-fold the value in intact animals. The specific atherosclerotic changes in this case occupied approximately 80% of the area of the thoracic aorta whose functional properties changed essentially. The values of constricting responses of bands to noradrenaline (NA) was 45% of that in intact rabbits, the dilatating responses to acetyl choline (AC) and nitroglycerin (NG) were 20% and 35% of those in intact animals, respectively. Combination of HCE with daily VP injection (1 mg) led to a decrease in the area of affection of the aorta by 20%, which hardly affected the severity of HCE. A slightly more pronounced than in animals only with HCE (controls) was the response of bands to NA, AC, and NG (by 5, 30, and 15%, respectively). The protective effect of MgCl2 (200 mg/kg) was more significant--the affected area of the thoracic aorta reduced by 50% as compared to the controls, the constricting response to NA was maintained at a level exceeding the control level by 25%, the dilatating responses to NG and AC exceeded the control values 2 and 1.5 times, respectively, on the average. The severity of HCE diminished by 50%. The results of the study indicate that the organic and, in particular, the inorganic blocking agents of the calcium canals possess a marked angioprotective action and may be applied for the prevention of vascular atherosclerosis.
作者研究了多种钙拮抗剂——维拉帕米（VP）和镁离子（MgCl₂）对长期高胆固醇血症（HCE）血管壁溃疡状况的影响特征。在HCE的第8个月末，血液胆固醇（CS）含量增加到正常动物的8倍。在这种情况下，特定的动脉粥样硬化变化占据了胸主动脉面积的约80%，其功能特性发生了本质变化。血管条对去甲肾上腺素（NA）的收缩反应值是正常兔的45%，对乙酰胆碱（AC）和硝酸甘油（NG）的舒张反应值分别是正常动物的20%和35%。HCE与每日注射VP（1毫克）相结合，使主动脉的病变面积减少了20%，这几乎未影响HCE的严重程度。血管条对NA、AC和NG的反应（分别增加5%、30%和15%）比仅患有HCE的动物（对照组）略为明显。MgCl₂（200毫克/千克）的保护作用更为显著——与对照组相比，胸主动脉的病变面积减少了50%，对NA的收缩反应维持在比对照水平高25%的水平，对NG和AC的舒张反应分别平均超过对照值2倍和1.5倍。HCE的严重程度降低了50%。研究结果表明，钙通道的有机尤其是无机阻滞剂具有显著的血管保护作用，可用于预防血管动脉粥样硬化。
