Dominguez Delfina C, Lopes Rosana, Torres M Lorraine
University of Texas at El Paso, Clinical Laboratory Science, College of Health Sciences, 1101 N. Campbell Street, El Paso, TX 79902-4238, USA.
Clin Lab Sci. 2007 Fall;20(4):245-8.
The word proteomics was coined in 1997 to describe the changes in all proteins expressed by a genome. Several sophisticated techniques including two-dimensional electrophoresis, imaging, mass spectrometry, and bioinformatics are used in proteomics to identify, quantify, and characterize proteins. Clinical proteomics is the application ofproteomics techniques to the medical field. The main aim of this methodology is to identify proteins involved in pathological processes and to understand how illness can lead to altered protein expression. Clinical proteomics offers the opportunity and the potential to develop new diagnostic and prognostic tests, to identify new therapeutic targets, and eventually to allow the design of individualized patient treatment. Here we present an overview of proteomics applications to the study of disease and its potential to improve diagnosis and prognosis.
“蛋白质组学”一词于1997年被创造出来，用于描述基因组所表达的所有蛋白质的变化。蛋白质组学使用了包括二维电泳、成像、质谱分析和生物信息学在内的多种精密技术来识别、定量和表征蛋白质。临床蛋白质组学是蛋白质组学技术在医学领域的应用。这种方法的主要目的是识别参与病理过程的蛋白质，并了解疾病如何导致蛋白质表达的改变。临床蛋白质组学为开发新的诊断和预后测试、识别新的治疗靶点以及最终实现个性化患者治疗方案的设计提供了机会和潜力。在此，我们概述蛋白质组学在疾病研究中的应用及其改善诊断和预后的潜力。
