[Progress in proteomics].

Proteomics, the large-scale analysis of proteins, will contribute greatly to our understanding of gene function in the post-genome era. Proteomics uses a combination of sophisticated techniques including two-dimensional(2D) gel electrophoresis, mass spectrometry, yeast two-hybrid system, bioinformatics, etc. to characterize, to quantify, and to analyze cellular proteins in a global way. The application of proteomics provides major opportunities to elucidate disease mechanisms and to identify new therapeutic targets. This review aims to explain the definition of proteomics and then to outline proteomic techniques. Finally, applications to the study of human disease are briefly discussed.