Jeremić B, Grujicić D, Jevremović S, Mijatović Lj
Department of Oncology, Clinical-Hospital Centre, Kragujevac.
Srp Arh Celok Lek. 1991 Sep-Oct;119(9-10):256-8.
BOPP chemotherapy regimen was introduced in patients with high-grade astrocytoma after surgery and radiotherapy. There were 10 anaplastic astrocytomas and 19 multiforme glioblastomas. Protocol consisted of BCNU 50 mg/m2, days 1-3, Vincristine 1,4 mg/m2 (max 2 mg), day 1, Procarbazine 50 mg/m2, days 1-7 and Cisplatin 20 mg/m2, days 1-3. All patients received at least three cycles of BOPP chemotherapy. The used toxicity criteria corresponded to ECOG. We observed 12 changes in WBC, 29 changes in haemoglobin, 18 changes in platelets and 11 changes in hematocrite. All patients had nausea and vomiting. We also observed 4 neurologic toxicities. Toxicities we observed responded favourably to standard means of therapy which can suggest either shortening of the interval between the cycles or increasing the dose per cycle.
BOPP化疗方案应用于高级别星形细胞瘤患者术后及放疗后。其中有10例间变性星形细胞瘤和19例多形性胶质母细胞瘤。方案包括：卡氮芥50mg/m²，第1 - 3天；长春新碱1.4mg/m²（最大2mg），第1天；甲基苄肼50mg/m²，第1 - 7天；顺铂20mg/m²，第1 - 3天。所有患者至少接受三个周期的BOPP化疗。所使用的毒性标准符合东部肿瘤协作组（ECOG）标准。我们观察到白细胞计数变化12例、血红蛋白变化29例、血小板变化18例、血细胞比容变化11例。所有患者均有恶心和呕吐症状。我们还观察到4例神经毒性反应。我们观察到的毒性反应对标准治疗方法反应良好，这可能提示缩短周期间隔或增加每个周期的剂量。
