Jeremić B, Barjaktarević Z, Mijatović L, Djurić L
K.B.C. Kragujevac, Department of Oncology and Nuclear Medicine, Yugoslavia.
J Chemother. 1990 Feb;2(1):67-9. doi: 10.1080/1120009x.1990.11738984.
Between January 1988 and October 1988, we treated 12 patients with glioblastoma multiforme with BOPP chemotherapy after surgery and radiotherapy. The protocol consisted of BCNU 50 mg/m2 days 1-3, vincristine 1.4 mg/m2 (maximum 2 mg) day 1, procarbazine 50 mg/m2, days 1-7 and cisplatinum 20 mg/m2, days 1-3. All patients had at least three courses of chemotherapy ECOG toxicity criteria were used. We observed 9/12 changes in WBC, 7/12 in Hgb. All patients had nausea and vomiting. We also observed 2/12 neuropathies related to CNS. Other toxicities were not observed.
