Miyata Takaki
Department of Anatomy and Cell Biology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466-8550, Japan.
Dev Growth Differ. 2008 Jun;50 Suppl 1:S105-12. doi: 10.1111/j.1440-169X.2007.00980.x. Epub 2007 Dec 7.
This review discusses the development of the neuroepithelium (NE) and its derivative ventricular zone (VZ), from which the central nervous system (CNS) is formed. First, the histological features of the NE and VZ are summarized, highlighting the phenomenon of pseudostratification, which is achieved by polarization and interkinetic nuclear migration (INM) of neural progenitor cells. Next, our current understanding of the cellular and molecular mechanisms and biological significance of INM and pseudostratification are outlined. The recent three-dimensional time-lapse observations revealing heterogeneity in cell lineages within the NE and VZ are also described, focusing on the neuronal lineage. Finally, the necessity of comprehensive studies on cell-cell interactions in the NE/VZ is discussed, as well as the importance of electrophysiological and biomechanical approaches. In particular, we suggest that a systems biology approach to the NE/VZ as a cellular 'community' may be fruitful.
本综述讨论了神经上皮（NE）及其衍生的脑室区（VZ）的发育，中枢神经系统（CNS）即由它们形成。首先，总结了NE和VZ的组织学特征，突出了假复层现象，这是通过神经祖细胞的极化和核内运动（INM）实现的。接下来，概述了我们目前对INM和假复层的细胞和分子机制及生物学意义的理解。还描述了最近的三维延时观察，揭示了NE和VZ内细胞谱系的异质性，重点是神经元谱系。最后，讨论了对NE/VZ中细胞间相互作用进行全面研究的必要性，以及电生理和生物力学方法的重要性。特别是，我们认为将系统生物学方法应用于作为细胞“群落”的NE/VZ可能会取得丰硕成果。
