视觉的第一个突触的发育和维持。
Development and maintenance of vision's first synapse.
机构信息
Huffington Center on Aging, Department of Neuroscience, Baylor College of Medicine, Houston, TX, 77030, USA.
Huffington Center on Aging, Department of Neuroscience, Baylor College of Medicine, Houston, TX, 77030, USA.
出版信息
Dev Biol. 2021 Aug;476:218-239. doi: 10.1016/j.ydbio.2021.04.001. Epub 2021 Apr 10.
Abstract
Synapses in the outer retina are the first information relay points in vision. Here, photoreceptors form synapses onto two types of interneurons, bipolar cells and horizontal cells. Because outer retina synapses are particularly large and highly ordered, they have been a useful system for the discovery of mechanisms underlying synapse specificity and maintenance. Understanding these processes is critical to efforts aimed at restoring visual function through repairing or replacing neurons and promoting their connectivity. We review outer retina neuron synapse architecture, neural migration modes, and the cellular and molecular pathways that play key roles in the development and maintenance of these connections. We further discuss how these mechanisms may impact connectivity in the retina.
摘要
外视网膜中的突触是视觉的第一个信息传递点。在这里，光感受器形成突触与两种类型的中间神经元，双极细胞和水平细胞。由于外视网膜突触特别大且高度有序，因此它们一直是发现突触特异性和维持机制的有用系统。了解这些过程对于通过修复或替换神经元并促进其连接来恢复视觉功能的努力至关重要。我们回顾了外视网膜神经元突触结构、神经迁移模式以及在这些连接的发育和维持中起关键作用的细胞和分子途径。我们还进一步讨论了这些机制如何影响视网膜中的连接。
相似文献
1
Development and maintenance of vision's first synapse.视觉的第一个突触的发育和维持。
Dev Biol. 2021 Aug;476:218-239. doi: 10.1016/j.ydbio.2021.04.001. Epub 2021 Apr 10.
2
How do horizontal cells 'talk' to cone photoreceptors? Different levels of complexity at the cone-horizontal cell synapse.水平细胞如何与视锥细胞“交流”？视锥细胞-水平细胞突触的不同复杂性层次。
J Physiol. 2017 Aug 15;595(16):5495-5506. doi: 10.1113/JP274177. Epub 2017 May 18.
3
Deafferented Adult Rod Bipolar Cells Create New Synapses with Photoreceptors to Restore Vision.去传入的成年视杆双极细胞与光感受器形成新突触以恢复视力。
J Neurosci. 2017 Apr 26;37(17):4635-4644. doi: 10.1523/JNEUROSCI.2570-16.2017. Epub 2017 Apr 3.
4
Ablation of retinal horizontal cells from adult mice leads to rod degeneration and remodeling in the outer retina.成年小鼠视网膜水平细胞消融导致外视网膜的 rod 变性和重塑。
J Neurosci. 2012 Aug 1;32(31):10713-24. doi: 10.1523/JNEUROSCI.0442-12.2012.
5
Immunocytochemical analysis of photoreceptors in the tiger salamander retina.虎蝾螈视网膜中光感受器的免疫细胞化学分析。
Vision Res. 2009 Jan;49(1):64-73. doi: 10.1016/j.visres.2008.09.031. Epub 2008 Nov 25.
6
Sequential pictorial presentation of neural interaction in the retina. 1. The synaptic ribbon complex.视网膜神经相互作用的顺序性图像展示。1. 突触带复合体。
J Submicrosc Cytol Pathol. 2001 Jul;33(3):313-21.
7
Structural and functional remodeling in the retina of a mouse with a photoreceptor synaptopathy: plasticity in the rod and degeneration in the cone system.患有光感受器突触病变的小鼠视网膜中的结构和功能重塑：视杆细胞的可塑性和视锥系统的退化。
Eur J Neurosci. 2007 Nov;26(9):2506-15. doi: 10.1111/j.1460-9568.2007.05886.x. Epub 2007 Oct 23.
8
A Presynaptic Group III mGluR Recruits Gβγ/SNARE Interactions to Inhibit Synaptic Transmission by Cone Photoreceptors in the Vertebrate Retina.突触前III组代谢型谷氨酸受体通过募集Gβγ/SNARE相互作用来抑制脊椎动物视网膜中视锥光感受器的突触传递。
J Neurosci. 2017 Apr 26;37(17):4618-4634. doi: 10.1523/JNEUROSCI.2948-16.2017. Epub 2017 Mar 31.
9
Rod and cone contributions to horizontal cell light responses in the mouse retina.视杆细胞和视锥细胞对小鼠视网膜水平细胞光反应的贡献。
J Neurosci. 2008 Jul 2;28(27):6818-25. doi: 10.1523/JNEUROSCI.1564-08.2008.
10
Synaptogenesis in the retina of the cat.猫视网膜中的突触形成
Brain Res. 1986 May 14;373(1-2):35-48. doi: 10.1016/0006-8993(86)90313-6.
引用本文的文献
1
Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features.早期人类光感受器状态及细胞状态特异性视网膜母细胞瘤相关特征的鉴定与表征
Elife. 2025 Aug 6;13:RP101918. doi: 10.7554/eLife.101918.
2
Neuroplastin 65 deficiency leads to the impairment of visual function through affecting ribbon synapse in retina of mice.神经纤连蛋白65缺乏通过影响小鼠视网膜中的带状突触导致视觉功能受损。
Front Cell Neurosci. 2025 May 8;19:1558334. doi: 10.3389/fncel.2025.1558334. eCollection 2025.
3
Molecular mechanism establishing the OFF pathway in vision.在视觉中建立OFF通路的分子机制。
Nat Commun. 2025 Apr 18;16(1):3708. doi: 10.1038/s41467-025-59046-0.
4
Molecular Components of Vesicle Cycling at the Rod Photoreceptor Ribbon Synapse.视杆光感受器带状突触处囊泡循环的分子成分
Adv Exp Med Biol. 2025;1468:325-330. doi: 10.1007/978-3-031-76550-6_54.
5
Complexin regulation of synaptic vesicle release: mechanisms in the central nervous system and specialized retinal ribbon synapses.突触结合蛋白对突触小泡释放的调控：中枢神经系统及特殊视网膜带状突触中的机制
Cell Commun Signal. 2024 Dec 3;22(1):581. doi: 10.1186/s12964-024-01942-x.
6
Host-Graft Synapses Form Functional Microstructures and Shape the Host Light Responses After Stem Cell-Derived Retinal Sheet Transplantation.宿主-移植物突触形成功能性微结构，并在干细胞衍生的视网膜片移植后塑造宿主的光反应。
Invest Ophthalmol Vis Sci. 2024 Oct 1;65(12):8. doi: 10.1167/iovs.65.12.8.
7
Zebrafish models of human-duplicated reveal novel functions in microglia and visual system development.人类重复基因的斑马鱼模型揭示了小胶质细胞和视觉系统发育中的新功能。
bioRxiv. 2024 Sep 27:2024.09.11.612570. doi: 10.1101/2024.09.11.612570.
8
Role of glutamate in the development of visual pathways.谷氨酸在视觉通路发育中的作用。
Front Ophthalmol (Lausanne). 2023 Mar 3;3:1147769. doi: 10.3389/fopht.2023.1147769. eCollection 2023.
9
Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features.早期人类光感受器状态及细胞状态特异性视网膜母细胞瘤相关特征的鉴定与表征
bioRxiv. 2024 Aug 22:2023.02.28.530247. doi: 10.1101/2023.02.28.530247.
10
Qualitative evaluations of reactive microglial heterogeneity in cultured porcine retina.培养猪视网膜中反应性小胶质细胞异质性的定性评价。
Histol Histopathol. 2024 Dec;39(12):1611-1620. doi: 10.14670/HH-18-772. Epub 2024 Jun 3.
本文引用的文献
1
LKB1 and AMPK instruct cone nuclear position to modify visual function.LKB1 和 AMPK 指示视锥细胞核位置以改变视觉功能。
Cell Rep. 2021 Feb 2;34(5):108698. doi: 10.1016/j.celrep.2021.108698.
2
Phosphorylation of the Retinal Ribbon Synapse Specific t-SNARE Protein Syntaxin3B Is Regulated by Light via a Ca-Dependent Pathway.视网膜带状突触特异性t-SNARE蛋白Syntaxin3B的磷酸化通过钙依赖途径受光调控。
Front Cell Neurosci. 2020 Oct 20;14:587072. doi: 10.3389/fncel.2020.587072. eCollection 2020.
3
Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.Munc13 异构体在视网膜突触中的异质前突触分布及具有 Munc13 异构体双重表达的非传统双极细胞类型的鉴定：使用 Munc13-EXFP 敲入小鼠的研究。
Int J Mol Sci. 2020 Oct 22;21(21):7848. doi: 10.3390/ijms21217848.
4
Dystrophin Is Required for the Proper Timing in Retinal Histogenesis: A Thorough Investigation on the Mouse Model of Duchenne Muscular Dystrophy.肌营养不良蛋白对视网膜组织发生的正确时间至关重要：对杜兴氏肌营养不良症小鼠模型的深入研究。
Front Neurosci. 2020 Aug 31;14:760. doi: 10.3389/fnins.2020.00760. eCollection 2020.
5
Stem/progenitor cell-based transplantation for retinal degeneration: a review of clinical trials.基于干细胞/祖细胞的移植治疗视网膜变性：临床试验综述。
Cell Death Dis. 2020 Sep 23;11(9):793. doi: 10.1038/s41419-020-02955-3.
6
Molecular and functional architecture of the mouse photoreceptor network.小鼠光感受器网络的分子与功能结构
Sci Adv. 2020 Jul 8;6(28):eaba7232. doi: 10.1126/sciadv.aba7232. eCollection 2020 Jul.
7
LKB1 coordinates neurite remodeling to drive synapse layer emergence in the outer retina.LKB1 协调神经突重塑，以推动外视网膜突触层的出现。
Elife. 2020 May 7;9:e56931. doi: 10.7554/eLife.56931.
8
Synaptic ribbons foster active zone stability and illumination-dependent active zone enrichment of RIM2 and Cav1.4 in photoreceptor synapses.突触带促进光感受器突触中活性区的稳定性和 RIM2 和 Cav1.4 对活性区的光照依赖性富集。
Sci Rep. 2020 Apr 6;10(1):5957. doi: 10.1038/s41598-020-62734-0.
9
Exceptional diversity of opsin expression patterns in (Stomatopoda) retinas.（十足目）复眼中视蛋白表达模式的非凡多样性。
Proc Natl Acad Sci U S A. 2020 Apr 21;117(16):8948-8957. doi: 10.1073/pnas.1917303117. Epub 2020 Apr 2.
10
The corepressor CtBP2 is required for proper development of the mouse cerebral cortex.抑制蛋白 CtBP2 对于小鼠大脑皮层的正常发育是必需的。
Mol Cell Neurosci. 2020 Apr;104:103481. doi: 10.1016/j.mcn.2020.103481. Epub 2020 Mar 10.
Zotero 插件