克伦特罗对兔尿道周围横纹肌收缩反应的影响。

Effect of clenbuterol on contractile response in periurethral striated muscle of rabbits.

作者信息

Kishimoto T, Morita T, Okamiya Y, Hoshina K, Takeshita T

机构信息

Pharmacological Research Department, Teijin Institute for Bio-Medical Research II, Tokyo.

出版信息

Tohoku J Exp Med. 1991 Nov;165(3):243-5. doi: 10.1620/tjem.165.243.

DOI:10.1620/tjem.165.243

PMID:1807013

Abstract

The effect of clenbuterol, a selective beta 2-adrenoceptor agonist, on isolated periurethral striated muscle preparations from rabbits has been investigated. The periurethral striated muscle produced a contraction in response to field stimulation. An application of clenbuterol resulted in a dose-dependent potentiation of the field stimulation-induced contraction. This potentiation was antagonized by propranolol and was greater than that of isoproterenol, suggesting a beta 2-agonistic action.

摘要

已对选择性β2肾上腺素能受体激动剂克伦特罗对兔离体尿道周围横纹肌制剂的作用进行了研究。尿道周围横纹肌对场刺激产生收缩反应。应用克伦特罗导致场刺激诱导的收缩呈剂量依赖性增强。这种增强作用被普萘洛尔拮抗，且大于异丙肾上腺素的作用，提示其具有β2激动作用。