Morita T
Nihon Hinyokika Gakkai Zasshi. 1989 Nov;80(11):1597-604. doi: 10.5980/jpnjurol1989.80.1597.
Terbutaline and clenbuterol, which are both selective beta 2-adrenoceptor agonists, produced a concentration-dependent decrease in contractile force of in vitro rabbit detrusor and proximal urethral smooth muscle. Conversely, terbutaline and clenbuterol produced a concentration-dependent increase in basal tension of in vitro rabbit external urethral striated muscle. Clenbuterol, orally administrated, produced an increase in urinary bladder capacity in cystometry and also an increase in maximal urethral closure pressure in urethral pressure profile. These results suggest that the beta 2-adrenoceptor agonist may be beneficial for urinary incontinent patients.
特布他林和克仑特罗均为选择性β2肾上腺素能受体激动剂，它们可使体外培养的兔逼尿肌和尿道近端平滑肌的收缩力呈浓度依赖性降低。相反，特布他林和克仑特罗可使体外培养的兔尿道外横纹肌的基础张力呈浓度依赖性增加。口服克仑特罗可使膀胱内压测量时膀胱容量增加，同时也可使尿道压力描记时最大尿道闭合压升高。这些结果表明，β2肾上腺素能受体激动剂可能对尿失禁患者有益。
